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• W2020051330 endingPage "275" @default.
• W2020051330 startingPage "264" @default.
• W2020051330 abstract "<h3>Abstract</h3> The need for safe and effective antiviral treatments is pressing, particularly given the number of viral infections that are prevalent in animal and human populations, often causing devastating economic losses and mortality. In the context of the current coronavirus pandemic, which has highlighted how devastating the effects of a virus can be on a naïve population, it is imperative to have rigorous and unbiased data on the efficacy and safety of potential antiviral treatments, particularly those that have demonstrated virucidal effects as a disinfectant, are being considered for use despite warnings on their potential toxicity, but no not have empirical evidence of their antiviral effect <i>in vivo</i>. Here, we tested the effect of chlorine dioxide (ClO₂) on chick embryos infected with avian infectious bronchitis coronavirus (IBV). We determined virus-induced mortality on 10-day old embryos inoculated with 10⁴ mean EID₅₀/mL of attenuated Massachusetts and Connecticut IBV strains. We determined viral titres using RT-qPCR and conducted histopathological examination of various tissues and organs. Viral titres were 2.4-fold lower and mortality was reduced by half in infected embryos that were treated with ClO₂. Infection led to developmental abnormalities regardless of treatment. Lesions typical of IBV infections were observed in all inoculated embryos, but severity tended to be lower in ClO₂-treated embryos. We found no gross or microscopic evidence of toxicity caused by ClO₂ at the doses used herein. Our study shows that ClO₂ could be a safe and viable option for controlling avian coronavirus, and raises the possibility that similar effects could be observed in other organisms." @default.
• W2020051330 created "2016-06-24" @default.
• W2020051330 creator A5064509518 @default.
• W2020051330 date "1972-09-01" @default.
• W2020051330 modified "2023-09-27" @default.
• W2020051330 title "The use of new staining techniques for human chromosome identification." @default.
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• W2020051330 doi "https://doi.org/10.1136/jmg.9.3.264" @default.
• W2020051330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1469153" @default.
• W2020051330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4116768" @default.
• W2020051330 hasPublicationYear "1972" @default.
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