Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020051710> ?p ?o ?g. }
- W2020051710 endingPage "e19" @default.
- W2020051710 startingPage "e18" @default.
- W2020051710 abstract "Background Colon carcinoma is a malignant tumour showing a marked preference to metastasise to distant organs. The presence of circulating tumour cells in the peripheral blood is a prerequisite for the formation of distant metastases. However, whether circulating cytokines are linked to the circulation of tumour cells, as individual cells or clusters, remains unclear. In this study, we investigated the circulating levels of TGF-β, CXCL1, VEGF, and PAI-1 as potential bioindicators of the presence of CTCs in patients with metastatic colon cancer. Methods CTCs were isolated from peripheral blood by immunomagnetic separation and phenotypically characterised in a cohort of 103 patients with metastatic colon cancer. TGF-β, CXCL1, VEGF, and PAI-1 concentrations were determined by immunoassay in plasma samples from the same patients. Findings We detected two different populations of CTCs, single cells or clusters, in patients with metastatic colon cancer. Within the single-cell population and according to the number of cells, we classified two groups of patients: 27 patients with a number of CTCs < 10 (CK1+/−) and 43 patients with CTCs ⩾ 10 (CK2+). Patients (n = 33) with clusters represented a unique group because we were unable to make any distinction. Presence of clusters is significantly associated with high plasma levels of TGF-beta and CXCL1 (p < 0.0001) and with reduced overall survival (OS); the median OS was 12, 27, and 54 months, respectively, in clustered, CK2+, and CK1+/− patient groups (p < 0.0001). Interpretation These findings show that detection of clustered CTCs represents a negative prognostic factor in patients with metastatic colon cancer. The presence of clustered CTCs is associated with elevated circulating levels of cytokines such as TGF-β and CXCL1. This finding suggests an additional role for circulating cytokines as a predictive tool for cancer prognosis and diagnosis of minimal residual disease, as well as assessment of tumour sensitivity to anticancer therapy. Colon carcinoma is a malignant tumour showing a marked preference to metastasise to distant organs. The presence of circulating tumour cells in the peripheral blood is a prerequisite for the formation of distant metastases. However, whether circulating cytokines are linked to the circulation of tumour cells, as individual cells or clusters, remains unclear. In this study, we investigated the circulating levels of TGF-β, CXCL1, VEGF, and PAI-1 as potential bioindicators of the presence of CTCs in patients with metastatic colon cancer. CTCs were isolated from peripheral blood by immunomagnetic separation and phenotypically characterised in a cohort of 103 patients with metastatic colon cancer. TGF-β, CXCL1, VEGF, and PAI-1 concentrations were determined by immunoassay in plasma samples from the same patients. We detected two different populations of CTCs, single cells or clusters, in patients with metastatic colon cancer. Within the single-cell population and according to the number of cells, we classified two groups of patients: 27 patients with a number of CTCs < 10 (CK1+/−) and 43 patients with CTCs ⩾ 10 (CK2+). Patients (n = 33) with clusters represented a unique group because we were unable to make any distinction. Presence of clusters is significantly associated with high plasma levels of TGF-beta and CXCL1 (p < 0.0001) and with reduced overall survival (OS); the median OS was 12, 27, and 54 months, respectively, in clustered, CK2+, and CK1+/− patient groups (p < 0.0001). These findings show that detection of clustered CTCs represents a negative prognostic factor in patients with metastatic colon cancer. The presence of clustered CTCs is associated with elevated circulating levels of cytokines such as TGF-β and CXCL1. This finding suggests an additional role for circulating cytokines as a predictive tool for cancer prognosis and diagnosis of minimal residual disease, as well as assessment of tumour sensitivity to anticancer therapy." @default.
- W2020051710 created "2016-06-24" @default.
- W2020051710 creator A5001852597 @default.
- W2020051710 creator A5004573667 @default.
- W2020051710 creator A5011902097 @default.
- W2020051710 creator A5018105976 @default.
- W2020051710 creator A5031620548 @default.
- W2020051710 creator A5034521737 @default.
- W2020051710 creator A5035706661 @default.
- W2020051710 creator A5039103241 @default.
- W2020051710 creator A5060464535 @default.
- W2020051710 creator A5061682882 @default.
- W2020051710 creator A5084396258 @default.
- W2020051710 creator A5085152226 @default.
- W2020051710 date "2014-05-01" @default.
- W2020051710 modified "2023-09-23" @default.
- W2020051710 title "P0036 The presence of clustered circulating tumour cells (CTCS) and circulating cytokines define an aggressive phenotype in metastatic colorectal cancer" @default.
- W2020051710 cites W1520425169 @default.
- W2020051710 cites W1543534779 @default.
- W2020051710 cites W1749922416 @default.
- W2020051710 cites W1969799659 @default.
- W2020051710 cites W1969927812 @default.
- W2020051710 cites W1972487267 @default.
- W2020051710 cites W1979242769 @default.
- W2020051710 cites W1980425877 @default.
- W2020051710 cites W1985727076 @default.
- W2020051710 cites W1986986419 @default.
- W2020051710 cites W1991225025 @default.
- W2020051710 cites W1991739120 @default.
- W2020051710 cites W1997782804 @default.
- W2020051710 cites W2001439351 @default.
- W2020051710 cites W2002260386 @default.
- W2020051710 cites W2009887475 @default.
- W2020051710 cites W2011394108 @default.
- W2020051710 cites W2011995257 @default.
- W2020051710 cites W2015611021 @default.
- W2020051710 cites W2028850312 @default.
- W2020051710 cites W2045886202 @default.
- W2020051710 cites W2057014130 @default.
- W2020051710 cites W2061256097 @default.
- W2020051710 cites W2065716393 @default.
- W2020051710 cites W2066085455 @default.
- W2020051710 cites W2086159554 @default.
- W2020051710 cites W2086641174 @default.
- W2020051710 cites W2090327853 @default.
- W2020051710 cites W2099556709 @default.
- W2020051710 cites W2107436924 @default.
- W2020051710 cites W2132431633 @default.
- W2020051710 cites W2134557975 @default.
- W2020051710 cites W2134878826 @default.
- W2020051710 cites W2136909908 @default.
- W2020051710 cites W2149535525 @default.
- W2020051710 cites W2151832198 @default.
- W2020051710 cites W2159187753 @default.
- W2020051710 cites W2414522906 @default.
- W2020051710 cites W2187627700 @default.
- W2020051710 doi "https://doi.org/10.1016/j.ejca.2014.03.080" @default.
- W2020051710 hasPublicationYear "2014" @default.
- W2020051710 type Work @default.
- W2020051710 sameAs 2020051710 @default.
- W2020051710 citedByCount "1" @default.
- W2020051710 countsByYear W20200517102016 @default.
- W2020051710 crossrefType "journal-article" @default.
- W2020051710 hasAuthorship W2020051710A5001852597 @default.
- W2020051710 hasAuthorship W2020051710A5004573667 @default.
- W2020051710 hasAuthorship W2020051710A5011902097 @default.
- W2020051710 hasAuthorship W2020051710A5018105976 @default.
- W2020051710 hasAuthorship W2020051710A5031620548 @default.
- W2020051710 hasAuthorship W2020051710A5034521737 @default.
- W2020051710 hasAuthorship W2020051710A5035706661 @default.
- W2020051710 hasAuthorship W2020051710A5039103241 @default.
- W2020051710 hasAuthorship W2020051710A5060464535 @default.
- W2020051710 hasAuthorship W2020051710A5061682882 @default.
- W2020051710 hasAuthorship W2020051710A5084396258 @default.
- W2020051710 hasAuthorship W2020051710A5085152226 @default.
- W2020051710 hasConcept C104317684 @default.
- W2020051710 hasConcept C121608353 @default.
- W2020051710 hasConcept C126322002 @default.
- W2020051710 hasConcept C127716648 @default.
- W2020051710 hasConcept C13373296 @default.
- W2020051710 hasConcept C142724271 @default.
- W2020051710 hasConcept C143998085 @default.
- W2020051710 hasConcept C2776914184 @default.
- W2020051710 hasConcept C2779013556 @default.
- W2020051710 hasConcept C2908647359 @default.
- W2020051710 hasConcept C502942594 @default.
- W2020051710 hasConcept C526805850 @default.
- W2020051710 hasConcept C55493867 @default.
- W2020051710 hasConcept C61238886 @default.
- W2020051710 hasConcept C71924100 @default.
- W2020051710 hasConcept C86803240 @default.
- W2020051710 hasConcept C96525457 @default.
- W2020051710 hasConcept C99454951 @default.
- W2020051710 hasConceptScore W2020051710C104317684 @default.
- W2020051710 hasConceptScore W2020051710C121608353 @default.
- W2020051710 hasConceptScore W2020051710C126322002 @default.
- W2020051710 hasConceptScore W2020051710C127716648 @default.
- W2020051710 hasConceptScore W2020051710C13373296 @default.