FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020052192> ?p ?o ?g. }

• W2020052192 endingPage "196" @default.
• W2020052192 startingPage "192" @default.
• W2020052192 abstract "The calcium ionophore, A23187, can induce rat hepatic metallothionein (MT) when administered in vivo (5.8-fold, 5.0 microM, 11 h) and rat hepatocyte MT when administered in vitro (10.70-fold, 1.0 microM, 24 h). Several rat hepatoma cell lines (2M, 4.55-fold; JM2, 12.29-fold; EC3, 14.12-fold; HTC, 7.99-fold) and a normal rat liver cell line (Clone 9, 39.67-fold) were tested for their inducibility of MT mRNA by Cd2+ (10 microM, 8 h). Quantitatively, JM2 and 2M made the most MT mRNA, while HTC made the least. A23187 (0.1-7.0 microM) was studied as an inducer of MT mRNA in these cell lines (except for HTC) and in HeLa. A variety of responses and tolerances were seen with inductions ranging up to 32.11-fold. Quantitatively, the best responding cell lines were EC3 and 2M. A combination induction experiment, using TPA, a protein kinase C activator, and A23187 in EC3 cells revealed an additive effect of the two inducers on MT mRNA levels: TPA (10 nM), 11.71-fold; A23187 (3.0 microM), 6.71-fold; and TPA + A23187, 20.00-fold. These studies have implicated perturbations in cytosolic calcium ion concentrations, caused by the ionophore A23187, as being involved in the complicated signaling systems which can lead to induction of MT mRNA and protein." @default.
• W2020052192 created "2016-06-24" @default.
• W2020052192 creator A5014115601 @default.
• W2020052192 creator A5059585512 @default.
• W2020052192 creator A5068566357 @default.
• W2020052192 creator A5082647900 @default.
• W2020052192 date "1992-03-09" @default.
• W2020052192 modified "2023-10-09" @default.
• W2020052192 title "Induction of zinc metallothionein by calcium ionophore in vivo and in vitro" @default.
• W2020052192 cites W1500700435 @default.
• W2020052192 cites W176145620 @default.
• W2020052192 cites W1831164682 @default.
• W2020052192 cites W1964839077 @default.
• W2020052192 cites W1978060911 @default.
• W2020052192 cites W19893031 @default.
• W2020052192 cites W1997806662 @default.
• W2020052192 cites W2000324336 @default.
• W2020052192 cites W2023969273 @default.
• W2020052192 cites W2033901635 @default.
• W2020052192 cites W2040566578 @default.
• W2020052192 cites W2072004570 @default.
• W2020052192 cites W2081704409 @default.
• W2020052192 cites W2103199749 @default.
• W2020052192 cites W2174107598 @default.
• W2020052192 cites W2188679199 @default.
• W2020052192 cites W2408823039 @default.
• W2020052192 cites W4252508261 @default.
• W2020052192 doi "https://doi.org/10.1016/0014-5793(92)80245-c" @default.
• W2020052192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1544493" @default.
• W2020052192 hasPublicationYear "1992" @default.
• W2020052192 type Work @default.
• W2020052192 sameAs 2020052192 @default.
• W2020052192 citedByCount "20" @default.
• W2020052192 countsByYear W20200521922012 @default.
• W2020052192 countsByYear W20200521922018 @default.
• W2020052192 crossrefType "journal-article" @default.
• W2020052192 hasAuthorship W2020052192A5014115601 @default.
• W2020052192 hasAuthorship W2020052192A5059585512 @default.
• W2020052192 hasAuthorship W2020052192A5068566357 @default.
• W2020052192 hasAuthorship W2020052192A5082647900 @default.
• W2020052192 hasConcept C104317684 @default.
• W2020052192 hasConcept C105580179 @default.
• W2020052192 hasConcept C150903083 @default.
• W2020052192 hasConcept C153911025 @default.
• W2020052192 hasConcept C170493617 @default.
• W2020052192 hasConcept C178790620 @default.
• W2020052192 hasConcept C181199279 @default.
• W2020052192 hasConcept C185592680 @default.
• W2020052192 hasConcept C202751555 @default.
• W2020052192 hasConcept C207001950 @default.
• W2020052192 hasConcept C20719415 @default.
• W2020052192 hasConcept C2225953 @default.
• W2020052192 hasConcept C2776200302 @default.
• W2020052192 hasConcept C2779014961 @default.
• W2020052192 hasConcept C519063684 @default.
• W2020052192 hasConcept C54355233 @default.
• W2020052192 hasConcept C55493867 @default.
• W2020052192 hasConcept C81885089 @default.
• W2020052192 hasConcept C86803240 @default.
• W2020052192 hasConcept C88045685 @default.
• W2020052192 hasConcept C98539663 @default.
• W2020052192 hasConceptScore W2020052192C104317684 @default.
• W2020052192 hasConceptScore W2020052192C105580179 @default.
• W2020052192 hasConceptScore W2020052192C150903083 @default.
• W2020052192 hasConceptScore W2020052192C153911025 @default.
• W2020052192 hasConceptScore W2020052192C170493617 @default.
• W2020052192 hasConceptScore W2020052192C178790620 @default.
• W2020052192 hasConceptScore W2020052192C181199279 @default.
• W2020052192 hasConceptScore W2020052192C185592680 @default.
• W2020052192 hasConceptScore W2020052192C202751555 @default.
• W2020052192 hasConceptScore W2020052192C207001950 @default.
• W2020052192 hasConceptScore W2020052192C20719415 @default.
• W2020052192 hasConceptScore W2020052192C2225953 @default.
• W2020052192 hasConceptScore W2020052192C2776200302 @default.
• W2020052192 hasConceptScore W2020052192C2779014961 @default.
• W2020052192 hasConceptScore W2020052192C519063684 @default.
• W2020052192 hasConceptScore W2020052192C54355233 @default.
• W2020052192 hasConceptScore W2020052192C55493867 @default.
• W2020052192 hasConceptScore W2020052192C81885089 @default.
• W2020052192 hasConceptScore W2020052192C86803240 @default.
• W2020052192 hasConceptScore W2020052192C88045685 @default.
• W2020052192 hasConceptScore W2020052192C98539663 @default.
• W2020052192 hasIssue "2" @default.
• W2020052192 hasLocation W20200521921 @default.
• W2020052192 hasLocation W20200521922 @default.
• W2020052192 hasOpenAccess W2020052192 @default.
• W2020052192 hasPrimaryLocation W20200521921 @default.
• W2020052192 hasRelatedWork W1507964404 @default.
• W2020052192 hasRelatedWork W1983842579 @default.
• W2020052192 hasRelatedWork W1990136542 @default.
• W2020052192 hasRelatedWork W2005767873 @default.
• W2020052192 hasRelatedWork W2011918669 @default.
• W2020052192 hasRelatedWork W2012903981 @default.
• W2020052192 hasRelatedWork W2094916416 @default.
• W2020052192 hasRelatedWork W2157865104 @default.
• W2020052192 hasRelatedWork W2410663883 @default.
• W2020052192 hasRelatedWork W4249640572 @default.
• W2020052192 hasVolume "299" @default.

• next