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- W2020056942 abstract "Abstract A collection of benzotriazoles consisting of seven compounds was prepared from the propynyl‐substituted benzolactone 1 and various azides using click chemistry. The lactone 1 was obtained through a short route by direct esterification of the allylbenzoic acid 9 with the alkynol 7 giving the benzoate 2 . The homopropargyl alcohol 7 in turn was obtained by opening the epoxide 6 with triisopropylsilyl acetylide. Ring‐closing metathesis of the ester 2 using Grubbs catalyst II followed by removal of the silicon protecting group furnished the lactone 1 . Two of the benzotriazoles, 17a and 17b , were also converted into the corresponding phenols to probe the role of the phenolic OH on the biological activity. All nine benzotriazoles showed cytotoxic activity in a L929 mouse fibroblast assay with IC 50 values in the low micromolar range. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)" @default.
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- W2020056942 date "2006-12-15" @default.
- W2020056942 modified "2023-10-09" @default.
- W2020056942 title "Synthesis of a Benzolactone Collection using Click Chemistry" @default.
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- W2020056942 doi "https://doi.org/10.1002/ejoc.200600681" @default.
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