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- W2020059513 abstract "3,4-Methylenedioxymethamphetamine (MDMA) (“Ecstasy”) produces neurotoxic effects, which result into an impairment of learning and memory and other neurological dysfunctions. We examined whether MDMA induces increases in tau protein phosphorylation, which are typically associated with Alzheimer's disease and other chronic neurodegenerative disorders. We injected mice with MDMA at cumulative doses of 10–50 mg/kg intraperitoneally, which are approximately equivalent to doses generally consumed by humans. MDMA enhanced the formation of reactive oxygen species and induced reactive gliosis in the hippocampus, without histological evidence of neuronal loss. An acute or 6 d treatment with MDMA increased tau protein phosphorylation in the hippocampus, revealed by both anti-phospho(Ser 404 )-tau and paired helical filament-1 antibodies. This increase was restricted to the CA2/CA3 subfields and lasted 1 and 7 d after acute and repeated MDMA treatment, respectively. Tau protein was phosphorylated as a result of two nonredundant mechanisms: (1) inhibition of the canonical Wnt (wingless-type MMTV integration site family) pathway, with ensuing activation of glycogen synthase kinase-3β; and (2) activation of type-5 cyclin-dependent kinase (Cdk5). MDMA induced the expression of the Wnt antagonist, Dickkopf-1, and the expression of the Cdk5-activating protein, p25. In addition, the increase in tau phosphorylation was attenuated by strategies that rescued the Wnt pathway or inhibited Cdk5. Finally, an impairment in hippocampus-dependent spatial learning was induced by doses of MDMA that increased tau phosphorylation, although the impairment outlasted this biochemical event. We conclude that tau hyperphosphorylation in the hippocampus may contribute to the impairment of learning and memory associated with MDMA abuse." @default.
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- W2020059513 date "2008-03-19" @default.
- W2020059513 modified "2023-10-16" @default.
- W2020059513 title "Enhanced Tau Phosphorylation in the Hippocampus of Mice Treated with 3,4-Methylenedioxymethamphetamine (“Ecstasy”)" @default.
- W2020059513 cites W1482198038 @default.
- W2020059513 cites W1490481380 @default.
- W2020059513 cites W1563116834 @default.
- W2020059513 cites W1577397450 @default.
- W2020059513 cites W1584535802 @default.
- W2020059513 cites W1660178166 @default.
- W2020059513 cites W1964927978 @default.
- W2020059513 cites W1965269533 @default.
- W2020059513 cites W1967073403 @default.
- W2020059513 cites W1969979382 @default.
- W2020059513 cites W1971468364 @default.
- W2020059513 cites W1973027772 @default.
- W2020059513 cites W1979268652 @default.
- W2020059513 cites W1983601892 @default.
- W2020059513 cites W1983903556 @default.
- W2020059513 cites W1985053970 @default.
- W2020059513 cites W1989118896 @default.
- W2020059513 cites W1990277146 @default.
- W2020059513 cites W1992491411 @default.
- W2020059513 cites W1993036354 @default.
- W2020059513 cites W1993762893 @default.
- W2020059513 cites W1995515835 @default.
- W2020059513 cites W1999966222 @default.
- W2020059513 cites W2000025977 @default.
- W2020059513 cites W2002839290 @default.
- W2020059513 cites W2003063237 @default.
- W2020059513 cites W2006718453 @default.
- W2020059513 cites W2008361014 @default.
- W2020059513 cites W2009875473 @default.
- W2020059513 cites W2012252010 @default.
- W2020059513 cites W2019258749 @default.
- W2020059513 cites W2024164417 @default.
- W2020059513 cites W2025657027 @default.
- W2020059513 cites W2030269068 @default.
- W2020059513 cites W2031179697 @default.
- W2020059513 cites W2031864556 @default.
- W2020059513 cites W2032924726 @default.
- W2020059513 cites W2034713237 @default.
- W2020059513 cites W2035179454 @default.
- W2020059513 cites W2036755018 @default.
- W2020059513 cites W2039265593 @default.
- W2020059513 cites W2040012768 @default.
- W2020059513 cites W2040147265 @default.
- W2020059513 cites W2041828918 @default.
- W2020059513 cites W2047427096 @default.
- W2020059513 cites W2051788298 @default.
- W2020059513 cites W2056961740 @default.
- W2020059513 cites W2058876115 @default.
- W2020059513 cites W2060414066 @default.
- W2020059513 cites W2061080184 @default.
- W2020059513 cites W2063540863 @default.
- W2020059513 cites W2064576666 @default.
- W2020059513 cites W2068257734 @default.
- W2020059513 cites W2075101325 @default.
- W2020059513 cites W2076209278 @default.
- W2020059513 cites W2077420576 @default.
- W2020059513 cites W2081319561 @default.
- W2020059513 cites W2081985759 @default.
- W2020059513 cites W2084810833 @default.
- W2020059513 cites W2085131134 @default.
- W2020059513 cites W2085689485 @default.
- W2020059513 cites W2086754177 @default.
- W2020059513 cites W2090237116 @default.
- W2020059513 cites W2092490886 @default.
- W2020059513 cites W2092765133 @default.
- W2020059513 cites W2092982594 @default.
- W2020059513 cites W2097021306 @default.
- W2020059513 cites W2097572806 @default.
- W2020059513 cites W2100352065 @default.
- W2020059513 cites W2120114673 @default.
- W2020059513 cites W2121610524 @default.
- W2020059513 cites W2126124658 @default.
- W2020059513 cites W2127700980 @default.
- W2020059513 cites W2127744736 @default.
- W2020059513 cites W2129946268 @default.
- W2020059513 cites W2132011757 @default.
- W2020059513 cites W2137627975 @default.
- W2020059513 cites W2138152051 @default.
- W2020059513 cites W2139607193 @default.
- W2020059513 cites W2158649743 @default.