FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020060125> ?p ?o ?g. }

• W2020060125 endingPage "6089" @default.
• W2020060125 startingPage "6082" @default.
• W2020060125 abstract "Mass spectrometry (MS) is the enabling technology for proteomics and metabolomics. However, dramatic improvements in both sensitivity and throughput are still required to achieve routine MS-based single cell proteomics and metabolomics. Here, we report the silicon-based monolithic multinozzle emitter array (MEA) and demonstrate its proof-of-principle applications in high-sensitivity and high-throughput nanoelectrospray mass spectrometry. Our MEA consists of 96 identical 10-nozzle emitters in a circular array on a 3 in. silicon chip. The geometry and configuration of the emitters, the dimension and number of the nozzles, and the micropillar arrays embedded in the main channel can be systematically and precisely controlled during the microfabrication process. Combining electrostatic simulation and experimental testing, we demonstrated that sharpened-end geometry at the stem of the individual multinozzle emitter significantly enhanced the electric fields at its protruding nozzle tips, enabling sequential nanoelectrospray for the high-density emitter array. We showed that electrospray current of the multinozzle emitter at a given total flow rate was approximately proportional to the square root of the number of its spraying-nozzles, suggesting the capability of high MS sensitivity for multinozzle emitters. Using a conventional Z-spray mass spectrometer, we demonstrated reproducible MS detection of peptides and proteins for serial MEA emitters, achieving sensitivity and stability comparable to the commercial capillary emitters. Our robust silicon-based MEA chip opens up the possibility of a fully integrated microfluidic system for ultrahigh-sensitivity and ultrahigh-throughput proteomics and metabolomics." @default.
• W2020060125 created "2016-06-24" @default.
• W2020060125 creator A5010426030 @default.
• W2020060125 creator A5020825492 @default.
• W2020060125 creator A5028846210 @default.
• W2020060125 creator A5064861904 @default.
• W2020060125 date "2011-07-05" @default.
• W2020060125 modified "2023-10-15" @default.
• W2020060125 title "Multinozzle Emitter Arrays for Nanoelectrospray Mass Spectrometry" @default.
• W2020060125 cites W1963643013 @default.
• W2020060125 cites W1965437384 @default.
• W2020060125 cites W1974736259 @default.
• W2020060125 cites W1976913681 @default.
• W2020060125 cites W1988035209 @default.
• W2020060125 cites W1990462184 @default.
• W2020060125 cites W1991107920 @default.
• W2020060125 cites W1994348463 @default.
• W2020060125 cites W2010637105 @default.
• W2020060125 cites W2011081598 @default.
• W2020060125 cites W2018495227 @default.
• W2020060125 cites W2021052195 @default.
• W2020060125 cites W2022557995 @default.
• W2020060125 cites W2027259751 @default.
• W2020060125 cites W2028264409 @default.
• W2020060125 cites W2029024859 @default.
• W2020060125 cites W2030355780 @default.
• W2020060125 cites W2031843548 @default.
• W2020060125 cites W2031884770 @default.
• W2020060125 cites W2033788565 @default.
• W2020060125 cites W2036009170 @default.
• W2020060125 cites W2055886903 @default.
• W2020060125 cites W2058016311 @default.
• W2020060125 cites W2064565086 @default.
• W2020060125 cites W2073292063 @default.
• W2020060125 cites W2079790345 @default.
• W2020060125 cites W2082121492 @default.
• W2020060125 cites W2086187432 @default.
• W2020060125 cites W2087047797 @default.
• W2020060125 cites W2093712919 @default.
• W2020060125 cites W2105976216 @default.
• W2020060125 cites W2107673330 @default.
• W2020060125 cites W2135461398 @default.
• W2020060125 cites W2140731996 @default.
• W2020060125 doi "https://doi.org/10.1021/ac2011813" @default.
• W2020060125 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3146565" @default.
• W2020060125 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21728281" @default.
• W2020060125 hasPublicationYear "2011" @default.
• W2020060125 type Work @default.
• W2020060125 sameAs 2020060125 @default.
• W2020060125 citedByCount "40" @default.
• W2020060125 countsByYear W20200601252012 @default.
• W2020060125 countsByYear W20200601252013 @default.
• W2020060125 countsByYear W20200601252014 @default.
• W2020060125 countsByYear W20200601252015 @default.
• W2020060125 countsByYear W20200601252016 @default.
• W2020060125 countsByYear W20200601252017 @default.
• W2020060125 countsByYear W20200601252018 @default.
• W2020060125 countsByYear W20200601252019 @default.
• W2020060125 countsByYear W20200601252020 @default.
• W2020060125 countsByYear W20200601252022 @default.
• W2020060125 countsByYear W20200601252023 @default.
• W2020060125 crossrefType "journal-article" @default.
• W2020060125 hasAuthorship W2020060125A5010426030 @default.
• W2020060125 hasAuthorship W2020060125A5020825492 @default.
• W2020060125 hasAuthorship W2020060125A5028846210 @default.
• W2020060125 hasAuthorship W2020060125A5064861904 @default.
• W2020060125 hasBestOaLocation W20200601252 @default.
• W2020060125 hasConcept C104317684 @default.
• W2020060125 hasConcept C113196181 @default.
• W2020060125 hasConcept C119599485 @default.
• W2020060125 hasConcept C121332964 @default.
• W2020060125 hasConcept C127413603 @default.
• W2020060125 hasConcept C136525101 @default.
• W2020060125 hasConcept C142724271 @default.
• W2020060125 hasConcept C162356407 @default.
• W2020060125 hasConcept C165005293 @default.
• W2020060125 hasConcept C171250308 @default.
• W2020060125 hasConcept C185592680 @default.
• W2020060125 hasConcept C192562407 @default.
• W2020060125 hasConcept C194451485 @default.
• W2020060125 hasConcept C204787440 @default.
• W2020060125 hasConcept C21200559 @default.
• W2020060125 hasConcept C24326235 @default.
• W2020060125 hasConcept C43617362 @default.
• W2020060125 hasConcept C46111723 @default.
• W2020060125 hasConcept C46918542 @default.
• W2020060125 hasConcept C49040817 @default.
• W2020060125 hasConcept C527607 @default.
• W2020060125 hasConcept C55493867 @default.
• W2020060125 hasConcept C56200935 @default.
• W2020060125 hasConcept C62520636 @default.
• W2020060125 hasConcept C70420769 @default.
• W2020060125 hasConcept C71924100 @default.
• W2020060125 hasConcept C82706917 @default.
• W2020060125 hasConcept C8673954 @default.
• W2020060125 hasConcept C97355855 @default.
• W2020060125 hasConceptScore W2020060125C104317684 @default.
• W2020060125 hasConceptScore W2020060125C113196181 @default.

• next