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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020060234> ?p ?o ?g. }

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• W2020060234 abstract "A series of Human Immunodeficiency Virus type-1 protease (HIV-1 PR) inhibitors that contain 3-amino-2-hydroxy-4-phenylbutanoic acid (AHPBA) at the scission site of the substrate were prepared and evaluated for their inhibitory activity. Preliminary studies on the chain length of inhibitors and the hydroxyl configuration of AHPBA indicated that small (2S,3S)-derivatives, composed of the regions between the P3 and P2' sites, showed enough inhibitory activity toward HIV-1 PR to become prototypes for further structural modification. Systematic replacement at the sites from P3 to P2' revealed that some bicyclic heteroarylcarbonyl derivatives possessed strong potency and good enzyme selectivity." @default.
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• W2020060234 date "1994-08-01" @default.
• W2020060234 modified "2023-10-16" @default.
• W2020060234 title "Structure-activity relationships of HIV-1 PR inhibitors containing AHPBA" @default.
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• W2020060234 doi "https://doi.org/10.1016/s0968-0896(00)82181-1" @default.
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