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• W2020060900 abstract "Four mutant clones independently derived from the Y1 mouse adrenocortical tumor cell line have adenylyl cyclase (AC) activities that are resistant to forskolin, a direct activator of AC. In this study the AC isoform composition of the forskolin-resistant mutants was examined in order to explore the underlying basis for the resistance to forskolin. As determined by Western blot and RT–PCR analysis, the four forskolin-resistant mutants all were deficient in AC-4; the levels of other AC isoforms (AC-1, AC-3 and AC-5/6) were comparable to the levels in parent Y1 cells. Transfection of one of the mutant clones with an AC-4 expression vector increased forskolin-stimulated cAMP signaling, and restored forskolin-induced changes in cell morphology and growth. Taken together, these observations indicate that AC-4 deficiency is a hallmark of the forskolin-resistant phenotype of these mutants and suggest that AC-4 is an important target of forskolin action in the Y1 adrenal cell line." @default.
• W2020060900 created "2016-06-24" @default.
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• W2020060900 date "2004-02-01" @default.
• W2020060900 modified "2023-10-01" @default.
• W2020060900 title "Forskolin-resistant Y1 adrenal cell mutants are deficient in adenylyl cyclase type 4" @default.
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• W2020060900 doi "https://doi.org/10.1016/j.mce.2003.10.066" @default.
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