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• W2020066082 abstract "<b><i>Objective:</i></b> The mortality rate of patients with poststernotomy mediastinitis remains very high. The aim of this study was to identify the risk factors associated with mortality in these patients. <b><i>Subjects and Methods:</i></b> Surveillance of sternal surgical-site infections including mediastinitis was carried out for adult patients undergoing a sternotomy between 2004 and 2012. Criteria from the US Centers for Disease Control and Prevention were used to make the diagnosis. All data on patients with a diagnosis of mediastinitis who were included in the study and on mortality risk factors were obtained from the hospital database and then analyzed using SPPS 16.0 for Windows. <b><i>Results:</i></b> Of the 19,767 patients undergoing open heart surgery, 117 (0.39%) had poststernotomy mediastinitis; 32% of these 117 died. The independent risk factors for mortality were methicillin-resistant <i>Staphylococcus aureus </i>(MRSA) [odds ratio (OR) 12.11 and 95% confidence interval (CI) 3.15-46.47], intensive-care unit stays >48 h after the first operation (OR 11.21 and 95% CI 3.24-38.84) and surgery that included valve replacement (OR 6.2 and 95% CI 1.44-27.13). The mortality rate decreased significantly, dropping from 38% (34/89) between 2004 and 2008 to 14% (4/28) between 2009 and 2012 (p = 0.018). <b><i>Conclusion:</i></b> In this study, elimination of MRSA from the hospital setting decreased the rate of mortality in patients with poststernotomy mediastinitis." @default.
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• W2020066082 date "2014-01-01" @default.
• W2020066082 modified "2023-09-27" @default.
• W2020066082 title "Methicillin-Resistant <b><i>Staphylococcus aureus </i></b>Infection: An Independent Risk Factor for Mortality in Patients with Poststernotomy Mediastinitis" @default.
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• W2020066082 doi "https://doi.org/10.1159/000365055" @default.
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