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- W2020070027 abstract "KAR2 encodes the yeast homologue of mammalian BiP, the endoplasmic reticulum (ER) resident member of the HSP70 family. Kar2p has been shown to be required for the translocation of proteins across the ER membrane as well as nuclear fusion. Sec63, an ER integral membrane protein that shares homology with the Escherichia coli DnaJ protein, is also required for translocation. In this paper we describe several specific genetic interactions between these two proteins, Kar2p and Sec63p. First, temperature-sensitive mutations in KAR2 and SEC63 form synthetic lethal combinations. Second, dominant mutations in KAR2 are allele-specific suppressors for the temperature-sensitive growth and translocation defect of sec63-1. Third, the sec63-1, unlike other translocation defective mutations, results in the induction of KAR2 mRNA levels. Taken together, these genetic interactions suggest that Kar2p and Sec63p interact in vivo in a manner similar to that of the E. coli HSP70, DnaK, and DnaJ. We propose that the interaction between these two proteins is critical to their function in protein translocation." @default.
- W2020070027 created "2016-06-24" @default.
- W2020070027 creator A5043015660 @default.
- W2020070027 creator A5050772644 @default.
- W2020070027 creator A5090888692 @default.
- W2020070027 date "1993-11-01" @default.
- W2020070027 modified "2023-09-25" @default.
- W2020070027 title "Genetic interactions between KAR2 and SEC63, encoding eukaryotic homologues of DnaK and DnaJ in the endoplasmic reticulum." @default.
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- W2020070027 doi "https://doi.org/10.1091/mbc.4.11.1145" @default.
- W2020070027 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/275750" @default.
- W2020070027 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8305736" @default.
- W2020070027 hasPublicationYear "1993" @default.
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