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• W2020071292 abstract "Background . Vitamin D has been reported to regulate innate immunity by controlling the expression of antimicrobial peptides (AMPs). Objective . We investigated the effect of calcipotriol on the expression of AMPs in human cultured keratinocytes. Methods . Keratinocytes were treated with lipopolysaccharide (LPS), TNF-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>α</mml:mi></mml:math>, Calcipotriol and irradiated with UVB, cultured, and harvested. To assess the expression of human beta defensin-2 and LL-37 in the control group, not exposed to any stimulants, the experimental group was treated with LPS, TNF-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>α</mml:mi></mml:math>, or UVB, and another group was treated again with calcipotriol; reverse transcriptase-polymerase chain reaction, Western blotting, and immunohistochemical staining were performed. Results . In the experimental group treated with LPS, UVB irradiation, and TNF-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>α</mml:mi></mml:math>, the expression of<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>β</mml:mi></mml:math>-defensin and LL-37 was increased more than in the control group and then decreased in the experimental group treated with calcipotriol. Conclusions . Calcipotriol suppressed HBD-2 and LL-37, which were stimulated by UVB, LPS, and TNF-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>α</mml:mi></mml:math>." @default.
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• W2020071292 date "2009-01-01" @default.
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• W2020071292 title "The Effect of Calcipotriol on the Expression of Human<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi mathvariant=bold>β</mml:mi></mml:math>Defensin-2 and LL-37 in Cultured Human Keratinocytes" @default.
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• W2020071292 doi "https://doi.org/10.1155/2009/645898" @default.
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