FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020071485> ?p ?o ?g. }

• W2020071485 endingPage "186" @default.
• W2020071485 startingPage "181" @default.
• W2020071485 abstract "Mycophenolic acid (MPA) and A77 1726, the active components of the immunosuppressants mycophenolate mophetil and leflunomide, respectively, in a dose-dependent manner inhibited interferon (IFN)-γ/LPS-induced interleukin (IL)-6 release in confluent cultures of mouse L929 fibrosarcoma cells. In addition, both drugs markedly reduced the production of the free radical gas nitric oxide (NO), without affecting the viability of L929 cells. The inhibitors of NO synthase, aminoguanidine and L-NMMA, but not L-NMMA inactive counterpart D-NMMA, mimicked the effects of A77 1726 and MPA on IL-6 generation in L929 fibroblasts. Furthermore, NO-releasing substance SNP completely reverted IL-6 accumulation in L929 cultures treated with A77 1726, while only partial recovery of IL-6 production was observed in the presence of MPA. MPA, but not A77 1726, significantly suppressed NO-independent IL-6 release triggered by cAMP-elevating agent rolipram. Thus, while A77 1726 effect on IL-6 production was mediated through concomitant reduction of NO synthesis, MPA action was mainly independent of the interference with NO generation. Finally, both agents inhibited IFN-γ/LPS-triggered IL-6 production in mouse primary fibroblasts, but not in mouse peritoneal macrophages, indicating cell-specificity of this novel anti-inflammatory action of A77 1726 and MPA." @default.
• W2020071485 created "2016-06-24" @default.
• W2020071485 creator A5059918331 @default.
• W2020071485 creator A5070648885 @default.
• W2020071485 creator A5079963522 @default.
• W2020071485 creator A5081210496 @default.
• W2020071485 creator A5082537654 @default.
• W2020071485 date "2002-08-01" @default.
• W2020071485 modified "2023-10-18" @default.
• W2020071485 title "IMMUNOSUPPRESSANTS LEFLUNOMIDE AND MYCOPHENOLIC ACID INHIBIT FIBROBLAST IL-6 PRODUCTION BY DISTINCT MECHANISMS" @default.
• W2020071485 cites W1943545698 @default.
• W2020071485 cites W1972463907 @default.
• W2020071485 cites W1976615163 @default.
• W2020071485 cites W1979811627 @default.
• W2020071485 cites W1982763713 @default.
• W2020071485 cites W1985557214 @default.
• W2020071485 cites W1988640455 @default.
• W2020071485 cites W1993779216 @default.
• W2020071485 cites W1997318094 @default.
• W2020071485 cites W2006833922 @default.
• W2020071485 cites W2033885400 @default.
• W2020071485 cites W2051444452 @default.
• W2020071485 cites W2052495191 @default.
• W2020071485 cites W2061904336 @default.
• W2020071485 cites W2063517103 @default.
• W2020071485 cites W2065018137 @default.
• W2020071485 cites W2070262526 @default.
• W2020071485 cites W2084629567 @default.
• W2020071485 cites W2085686909 @default.
• W2020071485 cites W2092805095 @default.
• W2020071485 cites W2119108876 @default.
• W2020071485 cites W2122308499 @default.
• W2020071485 cites W2140552959 @default.
• W2020071485 doi "https://doi.org/10.1006/cyto.2002.0885" @default.
• W2020071485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12297111" @default.
• W2020071485 hasPublicationYear "2002" @default.
• W2020071485 type Work @default.
• W2020071485 sameAs 2020071485 @default.
• W2020071485 citedByCount "18" @default.
• W2020071485 countsByYear W20200714852012 @default.
• W2020071485 countsByYear W20200714852014 @default.
• W2020071485 countsByYear W20200714852017 @default.
• W2020071485 countsByYear W20200714852019 @default.
• W2020071485 countsByYear W20200714852020 @default.
• W2020071485 countsByYear W20200714852022 @default.
• W2020071485 crossrefType "journal-article" @default.
• W2020071485 hasAuthorship W2020071485A5059918331 @default.
• W2020071485 hasAuthorship W2020071485A5070648885 @default.
• W2020071485 hasAuthorship W2020071485A5079963522 @default.
• W2020071485 hasAuthorship W2020071485A5081210496 @default.
• W2020071485 hasAuthorship W2020071485A5082537654 @default.
• W2020071485 hasConcept C126322002 @default.
• W2020071485 hasConcept C178790620 @default.
• W2020071485 hasConcept C185592680 @default.
• W2020071485 hasConcept C202751555 @default.
• W2020071485 hasConcept C203014093 @default.
• W2020071485 hasConcept C2775905006 @default.
• W2020071485 hasConcept C2778033501 @default.
• W2020071485 hasConcept C2779610285 @default.
• W2020071485 hasConcept C2780381497 @default.
• W2020071485 hasConcept C2781059491 @default.
• W2020071485 hasConcept C2911091166 @default.
• W2020071485 hasConcept C519581460 @default.
• W2020071485 hasConcept C55493867 @default.
• W2020071485 hasConcept C71924100 @default.
• W2020071485 hasConcept C86803240 @default.
• W2020071485 hasConcept C98274493 @default.
• W2020071485 hasConceptScore W2020071485C126322002 @default.
• W2020071485 hasConceptScore W2020071485C178790620 @default.
• W2020071485 hasConceptScore W2020071485C185592680 @default.
• W2020071485 hasConceptScore W2020071485C202751555 @default.
• W2020071485 hasConceptScore W2020071485C203014093 @default.
• W2020071485 hasConceptScore W2020071485C2775905006 @default.
• W2020071485 hasConceptScore W2020071485C2778033501 @default.
• W2020071485 hasConceptScore W2020071485C2779610285 @default.
• W2020071485 hasConceptScore W2020071485C2780381497 @default.
• W2020071485 hasConceptScore W2020071485C2781059491 @default.
• W2020071485 hasConceptScore W2020071485C2911091166 @default.
• W2020071485 hasConceptScore W2020071485C519581460 @default.
• W2020071485 hasConceptScore W2020071485C55493867 @default.
• W2020071485 hasConceptScore W2020071485C71924100 @default.
• W2020071485 hasConceptScore W2020071485C86803240 @default.
• W2020071485 hasConceptScore W2020071485C98274493 @default.
• W2020071485 hasIssue "4" @default.
• W2020071485 hasLocation W20200714851 @default.
• W2020071485 hasOpenAccess W2020071485 @default.
• W2020071485 hasPrimaryLocation W20200714851 @default.
• W2020071485 hasRelatedWork W1972167005 @default.
• W2020071485 hasRelatedWork W2014675838 @default.
• W2020071485 hasRelatedWork W2020071485 @default.
• W2020071485 hasRelatedWork W2052966837 @default.
• W2020071485 hasRelatedWork W2058090521 @default.
• W2020071485 hasRelatedWork W2362402452 @default.
• W2020071485 hasRelatedWork W2367679120 @default.
• W2020071485 hasRelatedWork W2380861561 @default.
• W2020071485 hasRelatedWork W2462451718 @default.
• W2020071485 hasRelatedWork W4302774236 @default.
• W2020071485 hasVolume "19" @default.

• next