Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020072944> ?p ?o ?g. }
- W2020072944 endingPage "F1615" @default.
- W2020072944 startingPage "F1606" @default.
- W2020072944 abstract "Angiotensin (ANG)-(1-7) is known to attenuate diabetic nephropathy; however, its role in the modulation of renal inflammation and oxidative stress in type 2 diabetes is poorly understood. Thus in the present study we evaluated the renal effects of a chronic ANG-(1-7) treatment in Zucker diabetic fatty rats (ZDF), an animal model of type 2 diabetes and nephropathy. Sixteen-week-old male ZDF and their respective controls [lean Zucker rats (LZR)] were used for this study. The protocol involved three groups: 1) LZR + saline, 2) ZDF + saline, and 3) ZDF + ANG-(1-7). For 2 wk, animals were implanted with subcutaneous osmotic pumps that delivered either saline or ANG-(1-7) (100 ng·kg(-1)·min(-1)) (n = 4). Renal fibrosis and tissue parameters of oxidative stress were determined. Also, renal levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), ED-1, hypoxia-inducible factor-1α (HIF-1α), and neutrophil gelatinase-associated lipocalin (NGAL) were determined by immunohistochemistry and immunoblotting. ANG-(1-7) induced a reduction in triglyceridemia, proteinuria, and systolic blood pressure (SBP) together with a restoration of creatinine clearance in ZDF. Additionally, ANG-(1-7) reduced renal fibrosis, decreased thiobarbituric acid-reactive substances, and restored the activity of both renal superoxide dismutase and catalase in ZDF. This attenuation of renal oxidative stress proceeded with decreased renal immunostaining of IL-6, TNF-α, ED-1, HIF-1α, and NGAL to values similar to those displayed by LZR. Angiotensin-converting enzyme type 2 (ACE2) and ANG II levels remained unchanged after treatment with ANG-(1-7). Chronic ANG-(1-7) treatment exerts a renoprotective effect in ZDF associated with a reduction of SBP, oxidative stress, and inflammatory markers. Thus ANG-(1-7) emerges as a novel target for treatment of diabetic nephropathy." @default.
- W2020072944 created "2016-06-24" @default.
- W2020072944 creator A5002212151 @default.
- W2020072944 creator A5003134867 @default.
- W2020072944 creator A5004150553 @default.
- W2020072944 creator A5016174385 @default.
- W2020072944 creator A5024520192 @default.
- W2020072944 creator A5029171401 @default.
- W2020072944 creator A5031409186 @default.
- W2020072944 creator A5049997446 @default.
- W2020072944 creator A5060412196 @default.
- W2020072944 date "2012-06-15" @default.
- W2020072944 modified "2023-09-29" @default.
- W2020072944 title "Angiotensin-(1–7) attenuates diabetic nephropathy in Zucker diabetic fatty rats" @default.
- W2020072944 cites W1520957183 @default.
- W2020072944 cites W1590457525 @default.
- W2020072944 cites W1938800934 @default.
- W2020072944 cites W1974140492 @default.
- W2020072944 cites W1977424733 @default.
- W2020072944 cites W1980042008 @default.
- W2020072944 cites W1985514124 @default.
- W2020072944 cites W1993746543 @default.
- W2020072944 cites W2000040025 @default.
- W2020072944 cites W2000130658 @default.
- W2020072944 cites W2001370885 @default.
- W2020072944 cites W2004840558 @default.
- W2020072944 cites W2005651168 @default.
- W2020072944 cites W2007064404 @default.
- W2020072944 cites W2026328040 @default.
- W2020072944 cites W2028404765 @default.
- W2020072944 cites W2028439883 @default.
- W2020072944 cites W2044437167 @default.
- W2020072944 cites W2053710318 @default.
- W2020072944 cites W2054364570 @default.
- W2020072944 cites W2054704564 @default.
- W2020072944 cites W2054960859 @default.
- W2020072944 cites W2056323849 @default.
- W2020072944 cites W2060352484 @default.
- W2020072944 cites W2061786959 @default.
- W2020072944 cites W2062786004 @default.
- W2020072944 cites W2063337868 @default.
- W2020072944 cites W2069775587 @default.
- W2020072944 cites W2079837239 @default.
- W2020072944 cites W2083695720 @default.
- W2020072944 cites W2090969480 @default.
- W2020072944 cites W2094023007 @default.
- W2020072944 cites W2097334774 @default.
- W2020072944 cites W2100238516 @default.
- W2020072944 cites W2101474131 @default.
- W2020072944 cites W2105731956 @default.
- W2020072944 cites W2106321093 @default.
- W2020072944 cites W2109970626 @default.
- W2020072944 cites W2117892119 @default.
- W2020072944 cites W2120001839 @default.
- W2020072944 cites W2122092984 @default.
- W2020072944 cites W2125236275 @default.
- W2020072944 cites W2141515134 @default.
- W2020072944 cites W2143393407 @default.
- W2020072944 cites W2147507671 @default.
- W2020072944 cites W2147593220 @default.
- W2020072944 cites W2151150148 @default.
- W2020072944 cites W2164367548 @default.
- W2020072944 cites W2170502745 @default.
- W2020072944 cites W2419072282 @default.
- W2020072944 cites W2913696875 @default.
- W2020072944 cites W2974701395 @default.
- W2020072944 doi "https://doi.org/10.1152/ajprenal.00063.2012" @default.
- W2020072944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22492942" @default.
- W2020072944 hasPublicationYear "2012" @default.
- W2020072944 type Work @default.
- W2020072944 sameAs 2020072944 @default.
- W2020072944 citedByCount "70" @default.
- W2020072944 countsByYear W20200729442012 @default.
- W2020072944 countsByYear W20200729442013 @default.
- W2020072944 countsByYear W20200729442014 @default.
- W2020072944 countsByYear W20200729442015 @default.
- W2020072944 countsByYear W20200729442016 @default.
- W2020072944 countsByYear W20200729442017 @default.
- W2020072944 countsByYear W20200729442018 @default.
- W2020072944 countsByYear W20200729442019 @default.
- W2020072944 countsByYear W20200729442020 @default.
- W2020072944 countsByYear W20200729442021 @default.
- W2020072944 countsByYear W20200729442022 @default.
- W2020072944 countsByYear W20200729442023 @default.
- W2020072944 crossrefType "journal-article" @default.
- W2020072944 hasAuthorship W2020072944A5002212151 @default.
- W2020072944 hasAuthorship W2020072944A5003134867 @default.
- W2020072944 hasAuthorship W2020072944A5004150553 @default.
- W2020072944 hasAuthorship W2020072944A5016174385 @default.
- W2020072944 hasAuthorship W2020072944A5024520192 @default.
- W2020072944 hasAuthorship W2020072944A5029171401 @default.
- W2020072944 hasAuthorship W2020072944A5031409186 @default.
- W2020072944 hasAuthorship W2020072944A5049997446 @default.
- W2020072944 hasAuthorship W2020072944A5060412196 @default.
- W2020072944 hasConcept C126322002 @default.
- W2020072944 hasConcept C134018914 @default.
- W2020072944 hasConcept C2776151105 @default.
- W2020072944 hasConcept C2779922275 @default.