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• W2020074098 abstract "Retinal melatonin biosynthesis is regulated in part by changes in the activity of serotonin N-acetyltransferase (NAT), which increases at night in dark-adapted retinas, but not in light-exposed retinas. Using an in vitro preparation of Xenopus laevis (African clawed frog) eye cups, we have obtained evidence supporting the involvement of gamma-aminobutyric acid (GABA) in the regulation of NAT activity. GABA, the GABA-A receptor agonists muscimol and isoguvacine, and the GABA-B receptor agonist (?)baclofen, in the presence of 3-isobutyl-1-methylxanthine, mimicked dark adaptation by increasing the activity of NAT in light-exposed retinas. The response to GABA agonists was not additive to that observed in darkness. Diazepam increased NAT activity of light-exposed retinas when added in the presence of muscimol, but had no significant effect when added alone. Picrotoxin, an antagonist of the GABA-A receptor-linked Cl(?) channel, blocked both the stimulation caused by dark adaptation and that caused by GABA-A agonists. The increase of NAT activity elicited by muscimol, but not that by baclofen, was blocked by bicuculline methobromide and picrotoxin. The results implicate GABA, acting through GABA-A and possibly GABA-B receptors, in the regulation of NAT activity in retina." @default.
• W2020074098 created "2016-06-24" @default.
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• W2020074098 date "1989-01-01" @default.
• W2020074098 modified "2023-09-24" @default.
• W2020074098 title "GABA and the regulation of serotonin N-acetyltransferase activity in amphibian retina—I. Effects of GABA agonists and antagonists" @default.
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• W2020074098 doi "https://doi.org/10.1016/0197-0186(89)90174-5" @default.
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