FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020075737> ?p ?o ?g. }

• W2020075737 endingPage "5981" @default.
• W2020075737 startingPage "5977" @default.
• W2020075737 abstract "Glc3Man9GlcNAc2 is the preferred substrate of the oligosaccharyltransferase of N-linked glycosylation of proteins, but nonglucosylated oligosaccharides can be transferred to proteins in Saccharomyces cerevisiae. Mutations affecting the addition of the three terminal glucose residues lead to accumulation of Man9GlcNAc2 or Glc1Man9GlcNAc2 in vivo but do not show any detectable growth defect. When these mutations were introduced into a strain with reduced oligosaccharyltransferase activity (due to the wbp1-1 mutation), a severe growth defect was observed: accumulation of suboptimal lipid-linked oligosaccharide and reduced oligosaccharyltransferase activity resulted in a severe underglycosylation of secreted proteins. This new synthetic phenotype made it possible to isolate the ALG8 locus, encoding a potential glucosyltransferase of the endoplasmic reticulum. The ALG8 protein is a 63.5-kDa hydrophobic protein that is not essential for the vegetative growth of yeast. However, the lack of this protein resulted in underglycosylation of secreted proteins." @default.
• W2020075737 created "2016-06-24" @default.
• W2020075737 creator A5009243617 @default.
• W2020075737 creator A5039402967 @default.
• W2020075737 creator A5058413134 @default.
• W2020075737 date "1994-06-21" @default.
• W2020075737 modified "2023-10-11" @default.
• W2020075737 title "New phenotype of mutations deficient in glucosylation of the lipid-linked oligosaccharide: cloning of the ALG8 locus." @default.
• W2020075737 cites W142386558 @default.
• W2020075737 cites W145894320 @default.
• W2020075737 cites W1482533850 @default.
• W2020075737 cites W1488791609 @default.
• W2020075737 cites W1516668213 @default.
• W2020075737 cites W1517052810 @default.
• W2020075737 cites W1520184049 @default.
• W2020075737 cites W1529542594 @default.
• W2020075737 cites W1570063124 @default.
• W2020075737 cites W1571990604 @default.
• W2020075737 cites W1593830682 @default.
• W2020075737 cites W1963486952 @default.
• W2020075737 cites W1970382205 @default.
• W2020075737 cites W1975304761 @default.
• W2020075737 cites W1975521726 @default.
• W2020075737 cites W2002370791 @default.
• W2020075737 cites W2007479961 @default.
• W2020075737 cites W2010168633 @default.
• W2020075737 cites W2022636296 @default.
• W2020075737 cites W2034300701 @default.
• W2020075737 cites W2034540836 @default.
• W2020075737 cites W2040518239 @default.
• W2020075737 cites W2115073295 @default.
• W2020075737 cites W2119388326 @default.
• W2020075737 cites W2124761552 @default.
• W2020075737 cites W2132417094 @default.
• W2020075737 cites W2151321483 @default.
• W2020075737 cites W2151585536 @default.
• W2020075737 cites W2152708819 @default.
• W2020075737 cites W320063903 @default.
• W2020075737 cites W67801743 @default.
• W2020075737 doi "https://doi.org/10.1073/pnas.91.13.5977" @default.
• W2020075737 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/44120" @default.
• W2020075737 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8016100" @default.
• W2020075737 hasPublicationYear "1994" @default.
• W2020075737 type Work @default.
• W2020075737 sameAs 2020075737 @default.
• W2020075737 citedByCount "91" @default.
• W2020075737 countsByYear W20200757372012 @default.
• W2020075737 countsByYear W20200757372013 @default.
• W2020075737 countsByYear W20200757372014 @default.
• W2020075737 countsByYear W20200757372015 @default.
• W2020075737 countsByYear W20200757372016 @default.
• W2020075737 countsByYear W20200757372018 @default.
• W2020075737 countsByYear W20200757372019 @default.
• W2020075737 countsByYear W20200757372020 @default.
• W2020075737 countsByYear W20200757372021 @default.
• W2020075737 countsByYear W20200757372022 @default.
• W2020075737 countsByYear W20200757372023 @default.
• W2020075737 crossrefType "journal-article" @default.
• W2020075737 hasAuthorship W2020075737A5009243617 @default.
• W2020075737 hasAuthorship W2020075737A5039402967 @default.
• W2020075737 hasAuthorship W2020075737A5058413134 @default.
• W2020075737 hasBestOaLocation W20200757372 @default.
• W2020075737 hasConcept C104317684 @default.
• W2020075737 hasConcept C108625454 @default.
• W2020075737 hasConcept C127716648 @default.
• W2020075737 hasConcept C158617107 @default.
• W2020075737 hasConcept C181199279 @default.
• W2020075737 hasConcept C206212055 @default.
• W2020075737 hasConcept C2777313579 @default.
• W2020075737 hasConcept C2777576037 @default.
• W2020075737 hasConcept C2777726330 @default.
• W2020075737 hasConcept C2777858569 @default.
• W2020075737 hasConcept C2779222958 @default.
• W2020075737 hasConcept C30324644 @default.
• W2020075737 hasConcept C55493867 @default.
• W2020075737 hasConcept C86803240 @default.
• W2020075737 hasConceptScore W2020075737C104317684 @default.
• W2020075737 hasConceptScore W2020075737C108625454 @default.
• W2020075737 hasConceptScore W2020075737C127716648 @default.
• W2020075737 hasConceptScore W2020075737C158617107 @default.
• W2020075737 hasConceptScore W2020075737C181199279 @default.
• W2020075737 hasConceptScore W2020075737C206212055 @default.
• W2020075737 hasConceptScore W2020075737C2777313579 @default.
• W2020075737 hasConceptScore W2020075737C2777576037 @default.
• W2020075737 hasConceptScore W2020075737C2777726330 @default.
• W2020075737 hasConceptScore W2020075737C2777858569 @default.
• W2020075737 hasConceptScore W2020075737C2779222958 @default.
• W2020075737 hasConceptScore W2020075737C30324644 @default.
• W2020075737 hasConceptScore W2020075737C55493867 @default.
• W2020075737 hasConceptScore W2020075737C86803240 @default.
• W2020075737 hasIssue "13" @default.
• W2020075737 hasLocation W20200757371 @default.
• W2020075737 hasLocation W20200757372 @default.
• W2020075737 hasLocation W20200757373 @default.
• W2020075737 hasOpenAccess W2020075737 @default.
• W2020075737 hasPrimaryLocation W20200757371 @default.
• W2020075737 hasRelatedWork W1561669317 @default.
• W2020075737 hasRelatedWork W164524425 @default.

• next