FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020076538> ?p ?o ?g. }

• W2020076538 endingPage "94" @default.
• W2020076538 startingPage "86" @default.
• W2020076538 abstract "Cyclooxygenase-2 (COX-2) overexpression is a widely recognized feature of human breast cancer and inhibitors of the enzyme have antitumor effects in a subset of tumor settings. Previously, we demonstrated that direct overexpression of COX-2 under control of the mammary-specific MMTV promoter/enhancer, was itself oncogenic and lead to the induction of mammary tumors in multiparous, outbred CD1 mice. In the present study, we provide evidence that COX-2 dependent tumor progression can also be studied in FVB/N, an inbred strain widely used for analysis of breast cancer progression. In these mice, the human COX-2 transgene was strongly induced during pregnancy/lactation and mammary tumors developed after multiple pregnancies. However, crossing the COX-2 FVB/N mice with the C57BL6 strain resulted in loss of the mammary tumorigenic phenotype despite the fact that the human COX-2 gene was induced. Treatment of the COX-2 transgenic mice in the FVB/N strain with celecoxib (1600 ppm), a COX-2 selective inhibitor, resulted significant reduction in tumor size and multiplicity when compared to transgenic mice fed with control chow. SC-560 (20 ppm), a COX-1 selective inhibitor did not have significant effect on tumorigenesis. These studies suggest that FVB/N is a susceptible mouse strain well suited to the study of COX-2 mediated tumor progression and may provide a tool for the identification of interacting genes and therapeutic treatments for this clinically important target." @default.
• W2020076538 created "2016-06-24" @default.
• W2020076538 creator A5006724562 @default.
• W2020076538 creator A5036507892 @default.
• W2020076538 creator A5037212651 @default.
• W2020076538 creator A5049950699 @default.
• W2020076538 creator A5084160891 @default.
• W2020076538 creator A5090527825 @default.
• W2020076538 date "2005-05-01" @default.
• W2020076538 modified "2023-10-04" @default.
• W2020076538 title "COX-2 inhibitors and genetic background reduce mammary tumorigenesis in cyclooxygenase-2 transgenic mice" @default.
• W2020076538 cites W1970050679 @default.
• W2020076538 cites W2023657377 @default.
• W2020076538 cites W2051686420 @default.
• W2020076538 cites W2067608498 @default.
• W2020076538 cites W2078872477 @default.
• W2020076538 cites W2088905899 @default.
• W2020076538 cites W2116168419 @default.
• W2020076538 cites W2123274778 @default.
• W2020076538 cites W2126853519 @default.
• W2020076538 cites W2145149010 @default.
• W2020076538 cites W2151113660 @default.
• W2020076538 cites W2165993802 @default.
• W2020076538 cites W2167250718 @default.
• W2020076538 cites W2316742206 @default.
• W2020076538 doi "https://doi.org/10.1016/j.prostaglandins.2005.01.002" @default.
• W2020076538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15967164" @default.
• W2020076538 hasPublicationYear "2005" @default.
• W2020076538 type Work @default.
• W2020076538 sameAs 2020076538 @default.
• W2020076538 citedByCount "22" @default.
• W2020076538 countsByYear W20200765382012 @default.
• W2020076538 countsByYear W20200765382013 @default.
• W2020076538 countsByYear W20200765382014 @default.
• W2020076538 countsByYear W20200765382016 @default.
• W2020076538 countsByYear W20200765382017 @default.
• W2020076538 countsByYear W20200765382018 @default.
• W2020076538 countsByYear W20200765382019 @default.
• W2020076538 countsByYear W20200765382021 @default.
• W2020076538 crossrefType "journal-article" @default.
• W2020076538 hasAuthorship W2020076538A5006724562 @default.
• W2020076538 hasAuthorship W2020076538A5036507892 @default.
• W2020076538 hasAuthorship W2020076538A5037212651 @default.
• W2020076538 hasAuthorship W2020076538A5049950699 @default.
• W2020076538 hasAuthorship W2020076538A5084160891 @default.
• W2020076538 hasAuthorship W2020076538A5090527825 @default.
• W2020076538 hasConcept C102230213 @default.
• W2020076538 hasConcept C104317684 @default.
• W2020076538 hasConcept C111936080 @default.
• W2020076538 hasConcept C121608353 @default.
• W2020076538 hasConcept C127716648 @default.
• W2020076538 hasConcept C141035611 @default.
• W2020076538 hasConcept C150194340 @default.
• W2020076538 hasConcept C181199279 @default.
• W2020076538 hasConcept C2776187077 @default.
• W2020076538 hasConcept C2778001805 @default.
• W2020076538 hasConcept C2779256057 @default.
• W2020076538 hasConcept C2779689624 @default.
• W2020076538 hasConcept C502942594 @default.
• W2020076538 hasConcept C530470458 @default.
• W2020076538 hasConcept C54355233 @default.
• W2020076538 hasConcept C55493867 @default.
• W2020076538 hasConcept C555283112 @default.
• W2020076538 hasConcept C86803240 @default.
• W2020076538 hasConceptScore W2020076538C102230213 @default.
• W2020076538 hasConceptScore W2020076538C104317684 @default.
• W2020076538 hasConceptScore W2020076538C111936080 @default.
• W2020076538 hasConceptScore W2020076538C121608353 @default.
• W2020076538 hasConceptScore W2020076538C127716648 @default.
• W2020076538 hasConceptScore W2020076538C141035611 @default.
• W2020076538 hasConceptScore W2020076538C150194340 @default.
• W2020076538 hasConceptScore W2020076538C181199279 @default.
• W2020076538 hasConceptScore W2020076538C2776187077 @default.
• W2020076538 hasConceptScore W2020076538C2778001805 @default.
• W2020076538 hasConceptScore W2020076538C2779256057 @default.
• W2020076538 hasConceptScore W2020076538C2779689624 @default.
• W2020076538 hasConceptScore W2020076538C502942594 @default.
• W2020076538 hasConceptScore W2020076538C530470458 @default.
• W2020076538 hasConceptScore W2020076538C54355233 @default.
• W2020076538 hasConceptScore W2020076538C55493867 @default.
• W2020076538 hasConceptScore W2020076538C555283112 @default.
• W2020076538 hasConceptScore W2020076538C86803240 @default.
• W2020076538 hasIssue "1-4" @default.
• W2020076538 hasLocation W20200765381 @default.
• W2020076538 hasLocation W20200765382 @default.
• W2020076538 hasOpenAccess W2020076538 @default.
• W2020076538 hasPrimaryLocation W20200765381 @default.
• W2020076538 hasRelatedWork W1488158769 @default.
• W2020076538 hasRelatedWork W151786199 @default.
• W2020076538 hasRelatedWork W1976599628 @default.
• W2020076538 hasRelatedWork W2021095327 @default.
• W2020076538 hasRelatedWork W2119074760 @default.
• W2020076538 hasRelatedWork W2145805228 @default.
• W2020076538 hasRelatedWork W2333275843 @default.
• W2020076538 hasRelatedWork W2471872694 @default.
• W2020076538 hasRelatedWork W3167101343 @default.
• W2020076538 hasRelatedWork W4243702031 @default.
• W2020076538 hasVolume "76" @default.

• next