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- W2020078971 abstract "The present study was conducted to evaluate effects of autoantlbodles In patients with Graves’ disease on Induction of c-fos and c-myc mRNA expression In rat thyroid cell line (FRTL5). IgG fractions were Isolated from 11 patients with Graves’ disease, and six healthy subjects, with protein A-Sepharose. FRTL5 cells which had been grown to subconfluency and deprived of TSH for a week were exposed to the IgG for an hour. Expression of c-fos and c-myc mRNAs was examined by the Northern blot method using nick-translated v-fos and c-myc probes. C-fos and c-myc transcripts were Induced by IgGs from two patients with Graves’ disease, which displayed much higher activities In assays for TSH binding Inhibitor Immuno-globullns, thyroid stimulating antibodies and thyroid growth-stimulating Immunoglobullns, assessed by measuring Inhibition of 125I-TSH binding to the TSH-receptor, cAMP production and 3H-thymldine Incorporation In FRTL5 cells, respectively, compared with those In the remaining patients. The Induction of c-fos and c-myc mRNAs by IgG from a patient with Graves’ disease was suppressed by prelncubatlon with IgGs from two patients with primary myxoedema who were known to have a blocking type TSH-receptor antibody. These data suggest that the binding of the antibodies to the TSH–receptor followed by cAMP production Is related to the induction of c-fos and c-myc mRNAs and, thus, to the growth of FRTL5 cells. To our knowledge, this Is the first report demonstrating that autoantibodies Induce proto-oncogene mRNA expression." @default.
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- W2020078971 date "1991-05-01" @default.
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- W2020078971 title "Induction of c-fos and c-myc mRNA expression by immunoglobulin G from patients with Graves’ disease in thyrotrophin-dependent rat thyroid cell line (FRTL5)" @default.
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- W2020078971 doi "https://doi.org/10.1111/j.1365-2265.1991.tb00304.x" @default.
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