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• W2020088788 abstract "Developmental mechanisms regulating gene expression and the stable acquisition of cell fate direct cytodifferentiation during organogenesis. Moreover, it is likely that such mechanisms could be exploited to repair or regenerate damaged organs. DNA methyltransferases (Dnmts) are enzymes critical for epigenetic regulation, and are used in concert with histone methylation and acetylation to regulate gene expression and maintain genomic integrity and chromosome structure. We carried out two forward genetic screens for regulators of endodermal organ development. In the first, we screened for altered morphology of developing digestive organs, while in the second we screed for the lack of terminally differentiated cell types in the pancreas and liver. From these screens, we identified two mutant alleles of zebrafish dnmt1. Both lesions are predicted to eliminate dnmt1 function; one is a missense mutation in the catalytic domain and the other is a nonsense mutation that eliminates the catalytic domain. In zebrafish dnmt1 mutants, the pancreas and liver form normally, but begin to degenerate after 84 h post fertilization (hpf). Acinar cells are nearly abolished through apoptosis by 100 hpf, though neither DNA replication, nor entry into mitosis is halted in the absence of detectable Dnmt1. However, endocrine cells and ducts are largely spared. Surprisingly, dnmt1 mutants and dnmt1 morpholino-injected larvae show increased capacity for pancreatic beta cell regeneration in an inducible model of pancreatic beta cell ablation. Thus, our data suggest that Dnmt1 is dispensable for pancreatic duct or endocrine cell formation, but not for acinar cell survival. In addition, Dnmt1 may influence the differentiation of pancreatic beta cell progenitors or the reprogramming of cells toward the pancreatic beta cell fate." @default.
• W2020088788 created "2016-06-24" @default.
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• W2020088788 date "2009-10-01" @default.
• W2020088788 modified "2023-10-03" @default.
• W2020088788 title "Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration" @default.
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• W2020088788 cites W1964620954 @default.
• W2020088788 cites W1966123083 @default.
• W2020088788 cites W1968483542 @default.
• W2020088788 cites W1969015262 @default.
• W2020088788 cites W1970864986 @default.
• W2020088788 cites W1974948144 @default.
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• W2020088788 cites W1990696681 @default.
• W2020088788 cites W1997524671 @default.
• W2020088788 cites W1998396050 @default.
• W2020088788 cites W2002261580 @default.
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• W2020088788 cites W2004440539 @default.
• W2020088788 cites W2014415534 @default.
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• W2020088788 cites W2018422177 @default.
• W2020088788 cites W2024298632 @default.
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• W2020088788 cites W2046204514 @default.
• W2020088788 cites W2046241907 @default.
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• W2020088788 cites W2071762384 @default.
• W2020088788 cites W2078443326 @default.
• W2020088788 cites W2084252683 @default.
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• W2020088788 doi "https://doi.org/10.1016/j.ydbio.2009.07.017" @default.
• W2020088788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2759669" @default.
• W2020088788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19631206" @default.
• W2020088788 hasPublicationYear "2009" @default.
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