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• W2020097327 endingPage "e1004295" @default.
• W2020097327 startingPage "e1004295" @default.
• W2020097327 abstract "HLA-restricted immune escape mutations that persist following HIV transmission could gradually spread through the viral population, thereby compromising host antiviral immunity as the epidemic progresses. To assess the extent and phenotypic impact of this phenomenon in an immunogenetically diverse population, we genotypically and functionally compared linked HLA and HIV (Gag/Nef) sequences from 358 historic (1979-1989) and 382 modern (2000-2011) specimens from four key cities in the North American epidemic (New York, Boston, San Francisco, Vancouver). Inferred HIV phylogenies were star-like, with approximately two-fold greater mean pairwise distances in modern versus historic sequences. The reconstructed epidemic ancestral (founder) HIV sequence was essentially identical to the North American subtype B consensus. Consistent with gradual diversification of a consensus-like founder virus, the median background frequencies of individual HLA-associated polymorphisms in HIV (in individuals lacking the restricting HLA[s]) were ∼ 2-fold higher in modern versus historic HIV sequences, though these remained notably low overall (e.g. in Gag, medians were 3.7% in the 2000s versus 2.0% in the 1980s). HIV polymorphisms exhibiting the greatest relative spread were those restricted by protective HLAs. Despite these increases, when HIV sequences were analyzed as a whole, their total average burden of polymorphisms that were pre-adapted to the average host HLA profile was only ∼ 2% greater in modern versus historic eras. Furthermore, HLA-associated polymorphisms identified in historic HIV sequences were consistent with those detectable today, with none identified that could explain the few HIV codons where the inferred epidemic ancestor differed from the modern consensus. Results are therefore consistent with slow HIV adaptation to HLA, but at a rate unlikely to yield imminent negative implications for cellular immunity, at least in North America. Intriguingly, temporal changes in protein activity of patient-derived Nef (though not Gag) sequences were observed, suggesting functional implications of population-level HIV evolution on certain viral proteins." @default.
• W2020097327 created "2016-06-24" @default.
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• W2020097327 date "2014-04-24" @default.
• W2020097327 modified "2023-10-01" @default.
• W2020097327 title "Genotypic and Functional Impact of HIV-1 Adaptation to Its Host Population during the North American Epidemic" @default.
• W2020097327 cites W1606271020 @default.
• W2020097327 cites W1623595668 @default.
• W2020097327 cites W1674854702 @default.
• W2020097327 cites W1846855295 @default.
• W2020097327 cites W1857725337 @default.
• W2020097327 cites W1956639982 @default.
• W2020097327 cites W1964895626 @default.
• W2020097327 cites W1970301294 @default.
• W2020097327 cites W1971877271 @default.
• W2020097327 cites W1977328931 @default.
• W2020097327 cites W1978277224 @default.
• W2020097327 cites W1978563162 @default.
• W2020097327 cites W1980888764 @default.
• W2020097327 cites W1986345390 @default.
• W2020097327 cites W1986362755 @default.
• W2020097327 cites W1986840254 @default.
• W2020097327 cites W1996464851 @default.
• W2020097327 cites W2007445829 @default.
• W2020097327 cites W2010218635 @default.
• W2020097327 cites W2014893636 @default.
• W2020097327 cites W2016759320 @default.
• W2020097327 cites W2023479104 @default.
• W2020097327 cites W2029353650 @default.
• W2020097327 cites W2030659576 @default.
• W2020097327 cites W2031830783 @default.
• W2020097327 cites W2032267362 @default.
• W2020097327 cites W2032763482 @default.
• W2020097327 cites W2045729285 @default.
• W2020097327 cites W2046229645 @default.
• W2020097327 cites W2049972436 @default.
• W2020097327 cites W2053695022 @default.
• W2020097327 cites W2056899326 @default.
• W2020097327 cites W2058205835 @default.
• W2020097327 cites W2058894986 @default.
• W2020097327 cites W2063485002 @default.
• W2020097327 cites W2063563723 @default.
• W2020097327 cites W2069926681 @default.
• W2020097327 cites W2070422630 @default.
• W2020097327 cites W2070519435 @default.
• W2020097327 cites W2073239402 @default.
• W2020097327 cites W2078844183 @default.
• W2020097327 cites W2085919513 @default.
• W2020097327 cites W2085984612 @default.
• W2020097327 cites W2087484510 @default.
• W2020097327 cites W2089615515 @default.
• W2020097327 cites W2091337695 @default.
• W2020097327 cites W2091662160 @default.
• W2020097327 cites W2092434970 @default.
• W2020097327 cites W2094939159 @default.
• W2020097327 cites W2095983332 @default.
• W2020097327 cites W2096015577 @default.
• W2020097327 cites W2096130477 @default.
• W2020097327 cites W2099182602 @default.
• W2020097327 cites W2099272076 @default.
• W2020097327 cites W2099364824 @default.
• W2020097327 cites W2102134348 @default.
• W2020097327 cites W2102820230 @default.
• W2020097327 cites W2103314023 @default.
• W2020097327 cites W2103920597 @default.
• W2020097327 cites W2106358727 @default.
• W2020097327 cites W2107186721 @default.
• W2020097327 cites W2108512869 @default.
• W2020097327 cites W2110299975 @default.
• W2020097327 cites W2110835349 @default.

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