FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020099265> ?p ?o ?g. }

• W2020099265 endingPage "253" @default.
• W2020099265 startingPage "249" @default.
• W2020099265 abstract "DEAD-box RNA helicases are vital for the regulation of various aspects of the RNA life cycle, but the molecular underpinnings of their involvement, particularly in mammalian cells, remain poorly understood. Here we show that the DEAD-box RNA helicase DDX21 can sense the transcriptional status of both RNA polymerase (Pol) I and II to control multiple steps of ribosome biogenesis in human cells. We demonstrate that DDX21 widely associates with Pol I- and Pol II-transcribed genes and with diverse species of RNA, most prominently with non-coding RNAs involved in the formation of ribonucleoprotein complexes, including ribosomal RNA, small nucleolar RNAs (snoRNAs) and 7SK RNA. Although broad, these molecular interactions, both at the chromatin and RNA level, exhibit remarkable specificity for the regulation of ribosomal genes. In the nucleolus, DDX21 occupies the transcribed rDNA locus, directly contacts both rRNA and snoRNAs, and promotes rRNA transcription, processing and modification. In the nucleoplasm, DDX21 binds 7SK RNA and, as a component of the 7SK small nuclear ribonucleoprotein (snRNP) complex, is recruited to the promoters of Pol II-transcribed genes encoding ribosomal proteins and snoRNAs. Promoter-bound DDX21 facilitates the release of the positive transcription elongation factor b (P-TEFb) from the 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes. Our results uncover the multifaceted role of DDX21 in multiple steps of ribosome biogenesis, and provide evidence implicating a mammalian RNA helicase in RNA modification and Pol II elongation control." @default.
• W2020099265 created "2016-06-24" @default.
• W2020099265 creator A5023437779 @default.
• W2020099265 creator A5040230088 @default.
• W2020099265 creator A5070785063 @default.
• W2020099265 creator A5070958907 @default.
• W2020099265 creator A5082224298 @default.
• W2020099265 creator A5084857406 @default.
• W2020099265 date "2014-11-24" @default.
• W2020099265 modified "2023-10-10" @default.
• W2020099265 title "RNA helicase DDX21 coordinates transcription and ribosomal RNA processing" @default.
• W2020099265 cites W109701900 @default.
• W2020099265 cites W1605366962 @default.
• W2020099265 cites W1676133928 @default.
• W2020099265 cites W1896034939 @default.
• W2020099265 cites W1967760633 @default.
• W2020099265 cites W1978560967 @default.
• W2020099265 cites W1979594866 @default.
• W2020099265 cites W1993374643 @default.
• W2020099265 cites W2002523565 @default.
• W2020099265 cites W2005650892 @default.
• W2020099265 cites W2005913043 @default.
• W2020099265 cites W2010615446 @default.
• W2020099265 cites W2013467101 @default.
• W2020099265 cites W2017099874 @default.
• W2020099265 cites W2057228860 @default.
• W2020099265 cites W2057325460 @default.
• W2020099265 cites W2064128480 @default.
• W2020099265 cites W2075122375 @default.
• W2020099265 cites W2076053308 @default.
• W2020099265 cites W2078532539 @default.
• W2020099265 cites W2081567150 @default.
• W2020099265 cites W2085670913 @default.
• W2020099265 cites W2109962448 @default.
• W2020099265 cites W2111236028 @default.
• W2020099265 cites W2114591008 @default.
• W2020099265 cites W2119860285 @default.
• W2020099265 cites W2123636860 @default.
• W2020099265 cites W2124552631 @default.
• W2020099265 cites W2132133477 @default.
• W2020099265 cites W2143432231 @default.
• W2020099265 cites W2147347134 @default.
• W2020099265 cites W2148252804 @default.
• W2020099265 cites W2151510603 @default.
• W2020099265 cites W2158482911 @default.
• W2020099265 cites W2162953684 @default.
• W2020099265 cites W2163636525 @default.
• W2020099265 cites W2170154747 @default.
• W2020099265 cites W4252230685 @default.
• W2020099265 doi "https://doi.org/10.1038/nature13923" @default.
• W2020099265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4827702" @default.
• W2020099265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25470060" @default.
• W2020099265 hasPublicationYear "2014" @default.
• W2020099265 type Work @default.
• W2020099265 sameAs 2020099265 @default.
• W2020099265 citedByCount "220" @default.
• W2020099265 countsByYear W20200992652015 @default.
• W2020099265 countsByYear W20200992652016 @default.
• W2020099265 countsByYear W20200992652017 @default.
• W2020099265 countsByYear W20200992652018 @default.
• W2020099265 countsByYear W20200992652019 @default.
• W2020099265 countsByYear W20200992652020 @default.
• W2020099265 countsByYear W20200992652021 @default.
• W2020099265 countsByYear W20200992652022 @default.
• W2020099265 countsByYear W20200992652023 @default.
• W2020099265 crossrefType "journal-article" @default.
• W2020099265 hasAuthorship W2020099265A5023437779 @default.
• W2020099265 hasAuthorship W2020099265A5040230088 @default.
• W2020099265 hasAuthorship W2020099265A5070785063 @default.
• W2020099265 hasAuthorship W2020099265A5070958907 @default.
• W2020099265 hasAuthorship W2020099265A5082224298 @default.
• W2020099265 hasAuthorship W2020099265A5084857406 @default.
• W2020099265 hasBestOaLocation W20200992652 @default.
• W2020099265 hasConcept C101762097 @default.
• W2020099265 hasConcept C104317684 @default.
• W2020099265 hasConcept C138885662 @default.
• W2020099265 hasConcept C150194340 @default.
• W2020099265 hasConcept C161223559 @default.
• W2020099265 hasConcept C172827444 @default.
• W2020099265 hasConcept C179255354 @default.
• W2020099265 hasConcept C179926584 @default.
• W2020099265 hasConcept C194993378 @default.
• W2020099265 hasConcept C25281209 @default.
• W2020099265 hasConcept C2779419633 @default.
• W2020099265 hasConcept C2908584439 @default.
• W2020099265 hasConcept C41258723 @default.
• W2020099265 hasConcept C41895202 @default.
• W2020099265 hasConcept C54355233 @default.
• W2020099265 hasConcept C64350747 @default.
• W2020099265 hasConcept C67705224 @default.
• W2020099265 hasConcept C68592252 @default.
• W2020099265 hasConcept C70916841 @default.
• W2020099265 hasConcept C75934600 @default.
• W2020099265 hasConcept C86803240 @default.
• W2020099265 hasConcept C88478588 @default.
• W2020099265 hasConcept C95444343 @default.
• W2020099265 hasConceptScore W2020099265C101762097 @default.
• W2020099265 hasConceptScore W2020099265C104317684 @default.

• next