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- W2020100102 abstract "Semantic dementia (SD) is one of the clinically defined phenotypes of pathologically defined frontotemporal lobar degeneration, characterized by loss of semantic memory and frontal and temporal lobe atrophy. Although previous studies have revealed naming disability was less severe and facial perception was more severe in patients with right-predominant temporal lobe atrophy compared to patients with left-predominant temporal lobe atrophy, detailed neuropsychological profiles in patients with right-predominant temporal lobe atrophy have not been well documented. We investigated neuropsychological profiles on each group. We performed neuropsychological batteries (Western Aphasia Battery (WAB), Wechsler Adult Intelligence Scale-III (WAIS-III) and Wechsler Memory Scale-Revised (WMS-R)) and neuroradiological assessments (brain MRI, SPECT, 13C PIB-PET) on 6 patients, who visited our hospital from 2009 to 2011 and diagnosed as SD. We compared neuropsychological profiles of patients with right-predominant temporal lobe atrophy to those of patients with left-predominant temporal lobe atrophy. Patients were aged 58 to 76 years (average 65.5 years). Among 6 patients, 2 patients showed right-predominant atrophy, the other 4 patients showed left-predominant temporal lobe atrophy. No difference was seen in the scores of WAIS-III and WMS-R between both groups. Although naming, word finding, reading and writing of WAB sub-profiles were impaired in both groups, some tests were relatively spared in patients with right-predominant temporal lobe atrophy (right-predominant atrophy/left-predominant atrophy: naming 53.3/20.0, word finding = 7.50/2.75 comprehension of sentences = 40.0/28.5, expressing in kanji = 28.25/13.50). Among patients diagnosed as SD, naming, word finding, comprehension of sentences and kanji writing were more spared in patients with right-predominant temporal lobe atrophy compared to patients with left-predominant temporal lobe atrophy. These results are related to less severe naming, word finding and writing disability in patients with right-predominant temporal lobe atrophy, compared to patients with left-predominant temporal lobe atrophy." @default.
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- W2020100102 date "2012-07-01" @default.
- W2020100102 modified "2023-10-02" @default.
- W2020100102 title "P1-176: Neuropsychological profiles in semantic dementia patients with right-hemisphere-predominant temporal lobe atrophy" @default.
- W2020100102 doi "https://doi.org/10.1016/j.jalz.2012.05.454" @default.
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