FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020100193> ?p ?o ?g. }

• W2020100193 endingPage "10107" @default.
• W2020100193 startingPage "10103" @default.
• W2020100193 abstract "Laboratory measures of antigen-specific immunity are an essential component of the vaccine discovery process. For human immunodeficiency virus type 1 (HIV-1), this process will likely require iterative evaluations of vaccine immunogens to choose the most promising vaccine candidates to advance into human trials. To optimally evaluate and compare vaccine immunogens, we will need high-throughput assays that allow accurate and reproducible measurements of immune responses. In addition, vaccine sponsors and regulatory agencies appropriately require that immune assays associated with human trials be performed in laboratories that comply with guidelines for good laboratory practices (GLP). The rigorous process of assay validation associated with GLP can improve the accuracy of immune assessment assays and contribute to vaccine development by advancing our ability to distinguish incremental improvements in immune responses elicited by novel immunogens. In this commentary, we address several of these issues with regard to the measurement of anti-HIV-1 neutralizing antibodies (NAbs). We recommend the use of DNA plasmids encoding full-length functional HIV-1 envelope glycoproteins (Env); these env clones, when transfected with an HIV-1 envdefective molecular clone, produce well-characterized HIV-1 Env pseudovirions. Additionally, we recommend the establishment of standardized panels of Env-pseudotyped viruses to assess the potencies and breadths of NAbs elicited by vaccine immunogens. These virus panels would form the basis for GLP neutralization assays used to assess sera from clinical vaccine studies, and the same virus panels could be used by investigators interested in the preclinical evaluation of vaccine immunogens." @default.
• W2020100193 created "2016-06-24" @default.
• W2020100193 creator A5004036928 @default.
• W2020100193 creator A5038341964 @default.
• W2020100193 creator A5041344472 @default.
• W2020100193 creator A5042931433 @default.
• W2020100193 creator A5043461622 @default.
• W2020100193 creator A5055153156 @default.
• W2020100193 creator A5061909491 @default.
• W2020100193 creator A5071657202 @default.
• W2020100193 creator A5074380743 @default.
• W2020100193 creator A5085731242 @default.
• W2020100193 date "2005-08-15" @default.
• W2020100193 modified "2023-10-17" @default.
• W2020100193 title "Recommendations for the Design and Use of Standard Virus Panels To Assess Neutralizing Antibody Responses Elicited by Candidate Human Immunodeficiency Virus Type 1 Vaccines" @default.
• W2020100193 cites W1480555318 @default.
• W2020100193 cites W1528520360 @default.
• W2020100193 cites W1549152468 @default.
• W2020100193 cites W1778074134 @default.
• W2020100193 cites W1975179872 @default.
• W2020100193 cites W1976086277 @default.
• W2020100193 cites W1984836566 @default.
• W2020100193 cites W1986103819 @default.
• W2020100193 cites W1988408958 @default.
• W2020100193 cites W1997677784 @default.
• W2020100193 cites W2000591768 @default.
• W2020100193 cites W2004986240 @default.
• W2020100193 cites W2005860294 @default.
• W2020100193 cites W2013908252 @default.
• W2020100193 cites W2024985647 @default.
• W2020100193 cites W2026990241 @default.
• W2020100193 cites W2034160159 @default.
• W2020100193 cites W2037793240 @default.
• W2020100193 cites W2037846530 @default.
• W2020100193 cites W2037855029 @default.
• W2020100193 cites W2039672486 @default.
• W2020100193 cites W2051052747 @default.
• W2020100193 cites W2057961805 @default.
• W2020100193 cites W2059124302 @default.
• W2020100193 cites W2060679290 @default.
• W2020100193 cites W2065329551 @default.
• W2020100193 cites W2080706877 @default.
• W2020100193 cites W2086044183 @default.
• W2020100193 cites W2091262391 @default.
• W2020100193 cites W2106876260 @default.
• W2020100193 cites W2110628058 @default.
• W2020100193 cites W2112353967 @default.
• W2020100193 cites W2126095200 @default.
• W2020100193 cites W2126255146 @default.
• W2020100193 cites W2130701915 @default.
• W2020100193 cites W2135691292 @default.
• W2020100193 cites W2140215666 @default.
• W2020100193 cites W2141861391 @default.
• W2020100193 cites W2146285125 @default.
• W2020100193 cites W2146704167 @default.
• W2020100193 cites W2152399881 @default.
• W2020100193 cites W2156178056 @default.
• W2020100193 cites W2157210912 @default.
• W2020100193 cites W2171750584 @default.
• W2020100193 cites W2329036584 @default.
• W2020100193 doi "https://doi.org/10.1128/jvi.79.16.10103-10107.2005" @default.
• W2020100193 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1182642" @default.
• W2020100193 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16051803" @default.
• W2020100193 hasPublicationYear "2005" @default.
• W2020100193 type Work @default.
• W2020100193 sameAs 2020100193 @default.
• W2020100193 citedByCount "235" @default.
• W2020100193 countsByYear W20201001932012 @default.
• W2020100193 countsByYear W20201001932013 @default.
• W2020100193 countsByYear W20201001932014 @default.
• W2020100193 countsByYear W20201001932015 @default.
• W2020100193 countsByYear W20201001932016 @default.
• W2020100193 countsByYear W20201001932017 @default.
• W2020100193 countsByYear W20201001932018 @default.
• W2020100193 countsByYear W20201001932019 @default.
• W2020100193 countsByYear W20201001932020 @default.
• W2020100193 countsByYear W20201001932021 @default.
• W2020100193 countsByYear W20201001932022 @default.
• W2020100193 countsByYear W20201001932023 @default.
• W2020100193 crossrefType "journal-article" @default.
• W2020100193 hasAuthorship W2020100193A5004036928 @default.
• W2020100193 hasAuthorship W2020100193A5038341964 @default.
• W2020100193 hasAuthorship W2020100193A5041344472 @default.
• W2020100193 hasAuthorship W2020100193A5042931433 @default.
• W2020100193 hasAuthorship W2020100193A5043461622 @default.
• W2020100193 hasAuthorship W2020100193A5055153156 @default.
• W2020100193 hasAuthorship W2020100193A5061909491 @default.
• W2020100193 hasAuthorship W2020100193A5071657202 @default.
• W2020100193 hasAuthorship W2020100193A5074380743 @default.
• W2020100193 hasAuthorship W2020100193A5085731242 @default.
• W2020100193 hasBestOaLocation W20201001931 @default.
• W2020100193 hasConcept C140704245 @default.
• W2020100193 hasConcept C159047783 @default.
• W2020100193 hasConcept C159654299 @default.
• W2020100193 hasConcept C196594336 @default.
• W2020100193 hasConcept C203014093 @default.
• W2020100193 hasConcept C2522874641 @default.
• W2020100193 hasConcept C2779261636 @default.

• next