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- W2020101834 endingPage "e56383" @default.
- W2020101834 startingPage "e56383" @default.
- W2020101834 abstract "Protein interaction modules coordinate the connections within and the activity of intracellular signaling networks. The Eps15 Homology (EH) module, a protein-protein interaction domain that is a key feature of the EH-network, was originally identified in a few proteins involved in endocytosis and vesicle trafficking, and has subsequently also been implicated in actin reorganization, nuclear shuttling, and DNA repair. Here we report an extensive characterization of the physical connections and of the functional wirings of the EH-network in the nematode. Our data show that one of the major physiological roles of the EH-network is in neurotransmission. In addition, we found that the proteins of the network intersect, and possibly coordinate, a number of territories of cellular activity including endocytosis/recycling/vesicle transport, actin dynamics, general metabolism and signal transduction, ubiquitination/degradation of proteins, DNA replication/repair, and miRNA biogenesis and processing." @default.
- W2020101834 created "2016-06-24" @default.
- W2020101834 creator A5000643937 @default.
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- W2020101834 creator A5048210131 @default.
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- W2020101834 creator A5067921407 @default.
- W2020101834 creator A5068831627 @default.
- W2020101834 creator A5071219878 @default.
- W2020101834 date "2013-02-12" @default.
- W2020101834 modified "2023-09-23" @default.
- W2020101834 title "A Snapshot of the Physical and Functional Wiring of the Eps15 Homology Domain Network in the Nematode" @default.
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