FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020102890> ?p ?o ?g. }

• W2020102890 endingPage "843" @default.
• W2020102890 startingPage "836" @default.
• W2020102890 abstract "Treatment of liver disease, caused by hepatotoxins, viral infections, alcohol ingestion, or autoimmune conditions, remains challenging and costly. The liver has a powerful capacity to repair and regenerate, thus a thorough understanding of this tightly orchestrated process will undoubtedly improve clinical means of restoring liver function after injury. Using a murine model of acute liver injury caused by overdose of acetaminophen (APAP), our studies demonstrated that the combined absence of liver resident macrophages (Kupffer cells, KCs), and infiltrating macrophages (IMs) resulted in a marked delay in liver repair, even though the initiation and extent of peak liver injury was not impacted. This delay was not due to impaired hepatocyte proliferation but rather prolonged vascular leakage, which is caused by APAP-induced liver sinusoidal endothelial cell (LSEC) injury. We also found that KCs and IMs express an array of angiogenic factors and induce LSEC proliferation and migration. Our mechanistic studies suggest that hypoxia-inducible factor (HIF) may be involved in regulating the angiogenic effect of hepatic macrophages (Macs), as we found that APAP challenge resulted in hypoxia and stabilization of HIF in the liver and hepatic Macs. Together, these data indicate an important role for hepatic Macs in liver blood vessel repair, thereby contributing to tissue recovery from acute injury." @default.
• W2020102890 created "2016-06-24" @default.
• W2020102890 creator A5008566785 @default.
• W2020102890 creator A5029372068 @default.
• W2020102890 creator A5051875418 @default.
• W2020102890 creator A5057631131 @default.
• W2020102890 creator A5082508377 @default.
• W2020102890 creator A5089703861 @default.
• W2020102890 date "2013-09-01" @default.
• W2020102890 modified "2023-10-18" @default.
• W2020102890 title "Role of hepatic resident and infiltrating macrophages in liver repair after acute injury" @default.
• W2020102890 cites W1574172480 @default.
• W2020102890 cites W1614484620 @default.
• W2020102890 cites W1972783950 @default.
• W2020102890 cites W1974975509 @default.
• W2020102890 cites W1985496701 @default.
• W2020102890 cites W1991079490 @default.
• W2020102890 cites W2000292756 @default.
• W2020102890 cites W2018643656 @default.
• W2020102890 cites W2050483870 @default.
• W2020102890 cites W2061763404 @default.
• W2020102890 cites W2065192517 @default.
• W2020102890 cites W2066930190 @default.
• W2020102890 cites W2070492917 @default.
• W2020102890 cites W2072861550 @default.
• W2020102890 cites W2073010239 @default.
• W2020102890 cites W2078036072 @default.
• W2020102890 cites W2078399688 @default.
• W2020102890 cites W2083950752 @default.
• W2020102890 cites W2091767953 @default.
• W2020102890 cites W2095537212 @default.
• W2020102890 cites W2095800957 @default.
• W2020102890 cites W2102929010 @default.
• W2020102890 cites W2104104624 @default.
• W2020102890 cites W2106982737 @default.
• W2020102890 cites W2109509015 @default.
• W2020102890 cites W2111550054 @default.
• W2020102890 cites W2112057120 @default.
• W2020102890 cites W2115825738 @default.
• W2020102890 cites W2123114542 @default.
• W2020102890 cites W2144578574 @default.
• W2020102890 cites W2146421436 @default.
• W2020102890 cites W2159362195 @default.
• W2020102890 cites W2163790438 @default.
• W2020102890 cites W4235300003 @default.
• W2020102890 cites W4313342476 @default.
• W2020102890 doi "https://doi.org/10.1016/j.bcp.2013.07.006" @default.
• W2020102890 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3863645" @default.
• W2020102890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23876342" @default.
• W2020102890 hasPublicationYear "2013" @default.
• W2020102890 type Work @default.
• W2020102890 sameAs 2020102890 @default.
• W2020102890 citedByCount "149" @default.
• W2020102890 countsByYear W20201028902014 @default.
• W2020102890 countsByYear W20201028902015 @default.
• W2020102890 countsByYear W20201028902016 @default.
• W2020102890 countsByYear W20201028902017 @default.
• W2020102890 countsByYear W20201028902018 @default.
• W2020102890 countsByYear W20201028902019 @default.
• W2020102890 countsByYear W20201028902020 @default.
• W2020102890 countsByYear W20201028902021 @default.
• W2020102890 countsByYear W20201028902022 @default.
• W2020102890 countsByYear W20201028902023 @default.
• W2020102890 crossrefType "journal-article" @default.
• W2020102890 hasAuthorship W2020102890A5008566785 @default.
• W2020102890 hasAuthorship W2020102890A5029372068 @default.
• W2020102890 hasAuthorship W2020102890A5051875418 @default.
• W2020102890 hasAuthorship W2020102890A5057631131 @default.
• W2020102890 hasAuthorship W2020102890A5082508377 @default.
• W2020102890 hasAuthorship W2020102890A5089703861 @default.
• W2020102890 hasBestOaLocation W20201028902 @default.
• W2020102890 hasConcept C126322002 @default.
• W2020102890 hasConcept C142724271 @default.
• W2020102890 hasConcept C149971331 @default.
• W2020102890 hasConcept C171056886 @default.
• W2020102890 hasConcept C178790620 @default.
• W2020102890 hasConcept C185592680 @default.
• W2020102890 hasConcept C202751555 @default.
• W2020102890 hasConcept C203014093 @default.
• W2020102890 hasConcept C2776200302 @default.
• W2020102890 hasConcept C2776637226 @default.
• W2020102890 hasConcept C2776795407 @default.
• W2020102890 hasConcept C2776914184 @default.
• W2020102890 hasConcept C2780394083 @default.
• W2020102890 hasConcept C29730261 @default.
• W2020102890 hasConcept C502942594 @default.
• W2020102890 hasConcept C540031477 @default.
• W2020102890 hasConcept C55493867 @default.
• W2020102890 hasConcept C71924100 @default.
• W2020102890 hasConcept C7836513 @default.
• W2020102890 hasConcept C86803240 @default.
• W2020102890 hasConcept C95444343 @default.
• W2020102890 hasConcept C98274493 @default.
• W2020102890 hasConceptScore W2020102890C126322002 @default.
• W2020102890 hasConceptScore W2020102890C142724271 @default.
• W2020102890 hasConceptScore W2020102890C149971331 @default.
• W2020102890 hasConceptScore W2020102890C171056886 @default.
• W2020102890 hasConceptScore W2020102890C178790620 @default.

• next