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• W2020105519 abstract "To the Editor: We were pleased to see the article by Jenisch et al. (Jenisch et al., 1998Jenisch S Henseler T Nair R Guo S Westphal E Stuart P Krønke M et al.Linkage analysis of human leukocyte antigen (HLA) markers in familial psoriasis: strong disequilibrium effects provide evidence for a major determinant in the HLA-B/-C region.Am J Hum Genet. 1998; 63: 191-199Abstract Full Text Full Text PDF PubMed Scopus (117) Google Scholar), providing additional evidence for linkage between (familial) psoriasis and human leukocyte antigen (HLA). This confirms, in partially new data, what we (Leder et al. Leder et al., 1998Leder RO Mansbridge JN Hallmayer J Hodge SE Familial psoriasis and HLA-B: unambiguous support for linkage in 97 published families.Hum Hered. 1998; 48: 198-211Crossref PubMed Scopus (30) Google Scholar) and others (Nair et al. Nair et al., 1997Nair R Henseler T Jenisch S Stuart P Bichakjian CK Lenk W Westphal E et al.Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan.Hum Mol Genet. 1997; 6: 1349-1356Crossref PubMed Scopus (357) Google Scholar; Trembath et al. Trembath et al., 1997Trembath RC Clough RL Rosbotham JL Jones AB Camp RDR Frodsham A Browne J et al.Identification of a major susceptibility locus on chromosome 6p and evidence for further disease loci revealed by a two-stage genome-wide search in psoriasis.Hum Mol Genet. 1997; 6: 813-820Crossref PubMed Scopus (440) Google Scholar) have already demonstrated—that there is a psoriasis susceptibility locus (PSORS1) on chromosome 6, closely linked to HLA. Unlike genome scans (Nair et al. Nair et al., 1997Nair R Henseler T Jenisch S Stuart P Bichakjian CK Lenk W Westphal E et al.Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan.Hum Mol Genet. 1997; 6: 1349-1356Crossref PubMed Scopus (357) Google Scholar; Trembath et al. Trembath et al., 1997Trembath RC Clough RL Rosbotham JL Jones AB Camp RDR Frodsham A Browne J et al.Identification of a major susceptibility locus on chromosome 6p and evidence for further disease loci revealed by a two-stage genome-wide search in psoriasis.Hum Mol Genet. 1997; 6: 813-820Crossref PubMed Scopus (440) Google Scholar), the analyses of Jenisch et al. (Jenisch et al., 1998Jenisch S Henseler T Nair R Guo S Westphal E Stuart P Krønke M et al.Linkage analysis of human leukocyte antigen (HLA) markers in familial psoriasis: strong disequilibrium effects provide evidence for a major determinant in the HLA-B/-C region.Am J Hum Genet. 1998; 63: 191-199Abstract Full Text Full Text PDF PubMed Scopus (117) Google Scholar) and our own analyses show that support for linkage is enhanced by use of haplotypes to account for HLA associations in linkage analysis. However, we note that Jenisch et al. (Jenisch et al., 1998Jenisch S Henseler T Nair R Guo S Westphal E Stuart P Krønke M et al.Linkage analysis of human leukocyte antigen (HLA) markers in familial psoriasis: strong disequilibrium effects provide evidence for a major determinant in the HLA-B/-C region.Am J Hum Genet. 1998; 63: 191-199Abstract Full Text Full Text PDF PubMed Scopus (117) Google Scholar) still hedge on the finding of linkage. Readers should be aware that our analyses of previously published data (Leder et al. Leder et al., 1998Leder RO Mansbridge JN Hallmayer J Hodge SE Familial psoriasis and HLA-B: unambiguous support for linkage in 97 published families.Hum Hered. 1998; 48: 198-211Crossref PubMed Scopus (30) Google Scholar) already support tight linkage beyond any reasonable doubt (LOD score of 23.7 under the assumption of dominant inheritance). The assertion by Jenisch et al. (Jenisch et al., 1998Jenisch S Henseler T Nair R Guo S Westphal E Stuart P Krønke M et al.Linkage analysis of human leukocyte antigen (HLA) markers in familial psoriasis: strong disequilibrium effects provide evidence for a major determinant in the HLA-B/-C region.Am J Hum Genet. 1998; 63: 191-199Abstract Full Text Full Text PDF PubMed Scopus (117) Google Scholar) that “Previous studies based on limited numbers of families found only weak evidence . . . for linkage to the HLA region” is also belied by our analysis of the previously published data. For example, the 31 families reported by Civatte et al. Civatte et al., 1977Civatte J Lazarovici C Ganas P Leon S Hors J Contu L Dausset J HLA system in psoriasis: study of 31 families.Ann Dermatol Venereol. 1977; 104: 525-532PubMed Google Scholar (cited in Jenisch et al. Jenisch et al., 1998Jenisch S Henseler T Nair R Guo S Westphal E Stuart P Krønke M et al.Linkage analysis of human leukocyte antigen (HLA) markers in familial psoriasis: strong disequilibrium effects provide evidence for a major determinant in the HLA-B/-C region.Am J Hum Genet. 1998; 63: 191-199Abstract Full Text Full Text PDF PubMed Scopus (117) Google Scholar) actually yield a LOD score of 6.29 between psoriasis and HLA-B, and family data from Sun et al. Sun et al., 1987Sun Y An J Li S Li H Chen W Lin L Xu L et al.HLA antigen distribution and haplotype segregation in Chinese patients with psoriasis.Chin Med J. 1987; 100: 236-241PubMed Google Scholar (not cited by Jenisch et al. Jenisch et al., 1998Jenisch S Henseler T Nair R Guo S Westphal E Stuart P Krønke M et al.Linkage analysis of human leukocyte antigen (HLA) markers in familial psoriasis: strong disequilibrium effects provide evidence for a major determinant in the HLA-B/-C region.Am J Hum Genet. 1998; 63: 191-199Abstract Full Text Full Text PDF PubMed Scopus (117) Google Scholar) yield a LOD score of 4.29. When the Civatte and Sun data are combined with data from other families reported previously (including all of those cited in Jenisch et al. Jenisch et al., 1998Jenisch S Henseler T Nair R Guo S Westphal E Stuart P Krønke M et al.Linkage analysis of human leukocyte antigen (HLA) markers in familial psoriasis: strong disequilibrium effects provide evidence for a major determinant in the HLA-B/-C region.Am J Hum Genet. 1998; 63: 191-199Abstract Full Text Full Text PDF PubMed Scopus (117) Google Scholar), evidence for linkage to psoriasis in the HLA region is overwhelming (summarized in table 3 of Leder et al. Leder et al., 1998Leder RO Mansbridge JN Hallmayer J Hodge SE Familial psoriasis and HLA-B: unambiguous support for linkage in 97 published families.Hum Hered. 1998; 48: 198-211Crossref PubMed Scopus (30) Google Scholar). Finally, we suggest that all investigators of HLA and psoriasis should use the official nomenclature for this psoriasis-susceptibility locus, PSORS1 (Leder et al. Leder et al., 1998Leder RO Mansbridge JN Hallmayer J Hodge SE Familial psoriasis and HLA-B: unambiguous support for linkage in 97 published families.Hum Hered. 1998; 48: 198-211Crossref PubMed Scopus (30) Google Scholar; White et al. White et al., 1998White J Maltais L Nebert D Networking nomenclature.Nat Genet. 1998; 18: 209Crossref PubMed Scopus (6) Google Scholar; see also White et al. White et al., 1999White J Maltais L Nebert D An increasingly urgent need for standardized gene nomenclature.Nat Genet. 1999; http://genetics.nature.com/web_specials/nomen/nomen_article.htmlGoogle Scholar). Now that HLA linkage in psoriasis is conclusively settled, it remains both to identify the HLA-linked psoriasis gene(s) and to solidify evidence for the putative role(s) of non-HLA genes in the genetic etiology of psoriasis." @default.
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• W2020105519 title "Psoriasis Linkage in the HLA Region" @default.
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