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- W2020107574 abstract "Possible promoting effects of 6-mercaptopurine (6-MP) on carcinogenesis in various organs, including the hematopoietic system, were investigated in female F344 rats, using a 2-stage carcinogenesis model. 6-MP was given as a dietary supplement (50 ppm) for 35 weeks subsequent to wide-spectrum initiation with N-ethyl-N-nitrosourea (ENU). Various tumors were observed in the carcinogen-initiated groups. No significant influence of 6-MP on their development, including the occurrence of leukemia, was apparent. However, the incidences of some proliferative lesions in the lung, intestine and kidney were slightly higher in the ENU/6-MP group than the ENU group. Further studies may be needed on promoting effects of 6-MP, based on dose-effect relation using several 6-MP doses and/or other initiators." @default.
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- W2020107574 date "1992-09-01" @default.
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- W2020107574 title "Promoting effects of 6-mercaptopurine on carcinogenesis in various organs of F344 rats" @default.
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- W2020107574 doi "https://doi.org/10.1016/0304-3835(92)90227-m" @default.
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