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- W2020108917 abstract "Histone deacetylase (HDAC) inhibitors have potential for cancer therapy. An HDAC inhibitor based on a cyclic peptide mimic of known structure, linked by an aliphatic chain to a hydroxamic acid, was designed and synthesized. The chimeric compound showed potent competitive inhibition of nuclear HDACs, with an IC50 value of 46 nM and a Ki value of 13.7 nM. The designed inhibitor showed 4-fold selectivity for HDAC1 (57 nM) over HDAC8 (231 nM)." @default.
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- W2020108917 date "2007-04-10" @default.
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- W2020108917 title "Design and Synthesis of a Potent Histone Deacetylase Inhibitor" @default.
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- W2020108917 doi "https://doi.org/10.1021/jm061082q" @default.
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