FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020109259> ?p ?o ?g. }

• W2020109259 endingPage "82" @default.
• W2020109259 startingPage "74" @default.
• W2020109259 abstract "A new model system for the study of phosphatidylcholine biosynthesis is presented. Young rats were fed a diet that contained 5% cholesterol and 2% cholate. After 6 days there was a 2-fold increase in the concentration of plasma phospholipid (243 mg/dl compared to 132 mg/dl for control animals) and a 3-fold increase in the concentration of plasma phosphatidylcholine. The rate of phosphatidylcholine biosynthesis was measured after injection of [Me-3H]choline into the portal veins. The incorporation of tritium into choline, phosphocholine and betaine by liver was similar for experimental and control animals, whereas there was a 3-fold increased incorporation into phosphatidylcholine of the cholesterolcholate-fed rats. The activities of the enzymes of phosphatidylcholine biosynthesis in cytosol and microsomes were assayed. The only change detected was in the cytosolic and microsomal activities of CTP: phosphocholine cytidylyltransferase which were increased more than 2-fold in specific activity. When total cytidylyltransferase activity per liver was determined, a dramatic translocation of the enzyme to microsomes was observed. The control livers had 24% of the cytidylyltransferase activity associated with microsomes, whereas this value was 61% in the livers from cholesterolcholate-fed rats. When the cytosolic cytidylyltransferase was assayed in the presence of phospholipid, the enzyme was stimulated several-fold and the difference in specific activity between control and cholesterolcholate-fed rats was abolished. The increased activity in cytosol appears to be the result of a 2-fold increase in the amount of phospholipid in the cytosol from cholesterolcholate-fed rats. The data strongly support the hypothesis that the special diet stimulates phosphatidylcholine biosynthesis by causing a translocation of the cytidylyltransferase from cytosol to microsomes where it is activated." @default.
• W2020109259 created "2016-06-24" @default.
• W2020109259 creator A5017396147 @default.
• W2020109259 creator A5025702019 @default.
• W2020109259 creator A5060062738 @default.
• W2020109259 creator A5061388687 @default.
• W2020109259 date "1983-08-01" @default.
• W2020109259 modified "2023-09-23" @default.
• W2020109259 title "Stimulation of hepatic phosphatidylcholine biosynthesis in rats fed a high cholesterol and cholate diet correlates with translocation of CTP:Phosphocholine cytidylyltransferase from cytosol to microsomes" @default.
• W2020109259 cites W1487589123 @default.
• W2020109259 cites W1499733109 @default.
• W2020109259 cites W1511715997 @default.
• W2020109259 cites W1514157157 @default.
• W2020109259 cites W1527593722 @default.
• W2020109259 cites W1541505284 @default.
• W2020109259 cites W1565685625 @default.
• W2020109259 cites W1581680249 @default.
• W2020109259 cites W1581909083 @default.
• W2020109259 cites W1604863183 @default.
• W2020109259 cites W1608533342 @default.
• W2020109259 cites W1615873781 @default.
• W2020109259 cites W162053295 @default.
• W2020109259 cites W1671239779 @default.
• W2020109259 cites W1966377283 @default.
• W2020109259 cites W1967981220 @default.
• W2020109259 cites W1979170691 @default.
• W2020109259 cites W1987339923 @default.
• W2020109259 cites W2009483599 @default.
• W2020109259 cites W2012858142 @default.
• W2020109259 cites W2013650172 @default.
• W2020109259 cites W2025716364 @default.
• W2020109259 cites W203002877 @default.
• W2020109259 cites W2035711602 @default.
• W2020109259 cites W2037773834 @default.
• W2020109259 cites W2057228946 @default.
• W2020109259 cites W2058033272 @default.
• W2020109259 cites W2075321309 @default.
• W2020109259 cites W2080704519 @default.
• W2020109259 cites W2093784804 @default.
• W2020109259 cites W2127908594 @default.
• W2020109259 cites W2152311269 @default.
• W2020109259 cites W2210370840 @default.
• W2020109259 cites W2233608365 @default.
• W2020109259 cites W2286693575 @default.
• W2020109259 cites W2318209409 @default.
• W2020109259 cites W2330667065 @default.
• W2020109259 cites W2414587558 @default.
• W2020109259 doi "https://doi.org/10.1016/0005-2760(83)90100-5" @default.
• W2020109259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6309244" @default.
• W2020109259 hasPublicationYear "1983" @default.
• W2020109259 type Work @default.
• W2020109259 sameAs 2020109259 @default.
• W2020109259 citedByCount "39" @default.
• W2020109259 countsByYear W20201092592013 @default.
• W2020109259 crossrefType "journal-article" @default.
• W2020109259 hasAuthorship W2020109259A5017396147 @default.
• W2020109259 hasAuthorship W2020109259A5025702019 @default.
• W2020109259 hasAuthorship W2020109259A5060062738 @default.
• W2020109259 hasAuthorship W2020109259A5061388687 @default.
• W2020109259 hasConcept C126322002 @default.
• W2020109259 hasConcept C134018914 @default.
• W2020109259 hasConcept C181199279 @default.
• W2020109259 hasConcept C185592680 @default.
• W2020109259 hasConcept C2776330855 @default.
• W2020109259 hasConcept C2776524530 @default.
• W2020109259 hasConcept C2776923060 @default.
• W2020109259 hasConcept C2778918659 @default.
• W2020109259 hasConcept C2780601828 @default.
• W2020109259 hasConcept C2781123555 @default.
• W2020109259 hasConcept C41625074 @default.
• W2020109259 hasConcept C553450214 @default.
• W2020109259 hasConcept C55493867 @default.
• W2020109259 hasConcept C71924100 @default.
• W2020109259 hasConcept C86803240 @default.
• W2020109259 hasConcept C87644729 @default.
• W2020109259 hasConcept C98539663 @default.
• W2020109259 hasConceptScore W2020109259C126322002 @default.
• W2020109259 hasConceptScore W2020109259C134018914 @default.
• W2020109259 hasConceptScore W2020109259C181199279 @default.
• W2020109259 hasConceptScore W2020109259C185592680 @default.
• W2020109259 hasConceptScore W2020109259C2776330855 @default.
• W2020109259 hasConceptScore W2020109259C2776524530 @default.
• W2020109259 hasConceptScore W2020109259C2776923060 @default.
• W2020109259 hasConceptScore W2020109259C2778918659 @default.
• W2020109259 hasConceptScore W2020109259C2780601828 @default.
• W2020109259 hasConceptScore W2020109259C2781123555 @default.
• W2020109259 hasConceptScore W2020109259C41625074 @default.
• W2020109259 hasConceptScore W2020109259C553450214 @default.
• W2020109259 hasConceptScore W2020109259C55493867 @default.
• W2020109259 hasConceptScore W2020109259C71924100 @default.
• W2020109259 hasConceptScore W2020109259C86803240 @default.
• W2020109259 hasConceptScore W2020109259C87644729 @default.
• W2020109259 hasConceptScore W2020109259C98539663 @default.
• W2020109259 hasIssue "1" @default.
• W2020109259 hasLocation W20201092591 @default.
• W2020109259 hasLocation W20201092592 @default.
• W2020109259 hasOpenAccess W2020109259 @default.
• W2020109259 hasPrimaryLocation W20201092591 @default.

• next