FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020110507> ?p ?o ?g. }

• W2020110507 endingPage "141" @default.
• W2020110507 startingPage "135" @default.
• W2020110507 abstract "The transient receptor potential vanilloid 1 (TRPV1) receptor is activated by noxious heat, various endogenous mediators and exogenous irritants. The aim of the present study was to compare three TRPV1 receptor antagonists (SB705498, BCTC and AMG9810) in rat models of heat hyperalgesia. The behavioural noxious heat threshold, defined as the lowest temperature evoking nocifensive reaction, was measured with an increasing-temperature water bath. The effects of TRPV1 receptor antagonists were assessed in thermal hyperalgesia induced by the TRPV1 agonist resiniferatoxin (RTX), mild heat injury (51 °C, 20 s) or plantar incision in rats. The control heat threshold was 43.2 ± 0.4 °C. RTX induced an 8–10 °C decrease in heat threshold which was dose-dependently inhibited by oral pre-treatment with any of the TRPV1 receptor antagonists with a minimum effective dose of 1 mg/kg. The mild heat injury-evoked 7–8 °C heat threshold drop was significantly reversed by all three antagonists injected i.p. as post-treatment. The minimum effective doses were as follows: SB705498 10, BCTC 3 and AMG9810 1 mg/kg. Plantar incision-induced heat threshold drop (7–8 °C) was dose-dependently diminished by an oral post-treatment with any of the antagonists with minimum effective doses of 10, 3 and 3 mg/kg, respectively. Assessment of RTX hyperalgesia by measurement of the paw withdrawal latency with a plantar test apparatus yielded 30 mg/kg minimum effective dose for each antagonist. In conclusion, measurement of the noxious heat threshold with the increasing-temperature water bath is suitable to sensitively detect the effects of TRPV1 receptor antagonists in thermal hyperalgesia models." @default.
• W2020110507 created "2016-06-24" @default.
• W2020110507 creator A5023105759 @default.
• W2020110507 creator A5032756567 @default.
• W2020110507 creator A5048598916 @default.
• W2020110507 creator A5056612513 @default.
• W2020110507 creator A5074860490 @default.
• W2020110507 creator A5078707797 @default.
• W2020110507 creator A5079050175 @default.
• W2020110507 creator A5082025917 @default.
• W2020110507 creator A5086614566 @default.
• W2020110507 date "2010-09-01" @default.
• W2020110507 modified "2023-10-18" @default.
• W2020110507 title "Effect of transient receptor potential vanilloid 1 (TRPV1) receptor antagonist compounds SB705498, BCTC and AMG9810 in rat models of thermal hyperalgesia measured with an increasing-temperature water bath" @default.
• W2020110507 cites W1492591187 @default.
• W2020110507 cites W1511198581 @default.
• W2020110507 cites W1942930266 @default.
• W2020110507 cites W1964531781 @default.
• W2020110507 cites W1965509871 @default.
• W2020110507 cites W1968805440 @default.
• W2020110507 cites W1970458977 @default.
• W2020110507 cites W1971261492 @default.
• W2020110507 cites W1984096754 @default.
• W2020110507 cites W1989508055 @default.
• W2020110507 cites W1998698456 @default.
• W2020110507 cites W2007034094 @default.
• W2020110507 cites W2008334989 @default.
• W2020110507 cites W2014007136 @default.
• W2020110507 cites W2042452061 @default.
• W2020110507 cites W2045592577 @default.
• W2020110507 cites W2046955207 @default.
• W2020110507 cites W2049100687 @default.
• W2020110507 cites W2050781058 @default.
• W2020110507 cites W2051684012 @default.
• W2020110507 cites W2063338540 @default.
• W2020110507 cites W2064911033 @default.
• W2020110507 cites W2066559312 @default.
• W2020110507 cites W2071564618 @default.
• W2020110507 cites W2087454739 @default.
• W2020110507 cites W2087677022 @default.
• W2020110507 cites W2102129421 @default.
• W2020110507 cites W2107705149 @default.
• W2020110507 cites W2107756388 @default.
• W2020110507 cites W2115903052 @default.
• W2020110507 cites W2118626190 @default.
• W2020110507 cites W2119832782 @default.
• W2020110507 cites W2127140021 @default.
• W2020110507 cites W2134742719 @default.
• W2020110507 cites W2149855043 @default.
• W2020110507 doi "https://doi.org/10.1016/j.ejphar.2010.05.052" @default.
• W2020110507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20534382" @default.
• W2020110507 hasPublicationYear "2010" @default.
• W2020110507 type Work @default.
• W2020110507 sameAs 2020110507 @default.
• W2020110507 citedByCount "34" @default.
• W2020110507 countsByYear W20201105072012 @default.
• W2020110507 countsByYear W20201105072013 @default.
• W2020110507 countsByYear W20201105072014 @default.
• W2020110507 countsByYear W20201105072015 @default.
• W2020110507 countsByYear W20201105072016 @default.
• W2020110507 countsByYear W20201105072017 @default.
• W2020110507 countsByYear W20201105072018 @default.
• W2020110507 countsByYear W20201105072019 @default.
• W2020110507 countsByYear W20201105072021 @default.
• W2020110507 countsByYear W20201105072022 @default.
• W2020110507 countsByYear W20201105072023 @default.
• W2020110507 crossrefType "journal-article" @default.
• W2020110507 hasAuthorship W2020110507A5023105759 @default.
• W2020110507 hasAuthorship W2020110507A5032756567 @default.
• W2020110507 hasAuthorship W2020110507A5048598916 @default.
• W2020110507 hasAuthorship W2020110507A5056612513 @default.
• W2020110507 hasAuthorship W2020110507A5074860490 @default.
• W2020110507 hasAuthorship W2020110507A5078707797 @default.
• W2020110507 hasAuthorship W2020110507A5079050175 @default.
• W2020110507 hasAuthorship W2020110507A5082025917 @default.
• W2020110507 hasAuthorship W2020110507A5086614566 @default.
• W2020110507 hasConcept C15490471 @default.
• W2020110507 hasConcept C155164980 @default.
• W2020110507 hasConcept C160145004 @default.
• W2020110507 hasConcept C170493617 @default.
• W2020110507 hasConcept C185592680 @default.
• W2020110507 hasConcept C2776354303 @default.
• W2020110507 hasConcept C2776885963 @default.
• W2020110507 hasConcept C2778122271 @default.
• W2020110507 hasConcept C2778938600 @default.
• W2020110507 hasConcept C2779245659 @default.
• W2020110507 hasConcept C55493867 @default.
• W2020110507 hasConcept C71924100 @default.
• W2020110507 hasConcept C98274493 @default.
• W2020110507 hasConceptScore W2020110507C15490471 @default.
• W2020110507 hasConceptScore W2020110507C155164980 @default.
• W2020110507 hasConceptScore W2020110507C160145004 @default.
• W2020110507 hasConceptScore W2020110507C170493617 @default.
• W2020110507 hasConceptScore W2020110507C185592680 @default.
• W2020110507 hasConceptScore W2020110507C2776354303 @default.
• W2020110507 hasConceptScore W2020110507C2776885963 @default.
• W2020110507 hasConceptScore W2020110507C2778122271 @default.
• W2020110507 hasConceptScore W2020110507C2778938600 @default.

• next