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- W2020111689 abstract "Abstract Male rats administered [14C]phenobarbitone (50 mg/kg) or [14C]-pentobarbitone (30 mg/kg) simultaneously with either 15% ethanol (3 g/kg) or saline intraperitoneally were killed 5, 10 or 20 min after injection. The radioactivity in the blood, whole brain and different brain areas was measured. Phenobarbitone was absorbed more slowly into the blood and brain than pentobarbitone. Ethanol-treated rats had significantly higher phenobarbitone concentrations than the saline-treated controls in the blood, whole brain, cerebrum and cerebellum up to 10 min after injection. Pentobarbitone concentrations were not significantly altered by ethanol. Barbiturate concentrations in the cerebral cortex were lower than in other regions of the brain. The brain: blood barbiturate ratios were not appreciably changed by ethanol. It is concluded that ethanol (15%) given intraperitoneally aided the transport of phenobarbitone across the peritoneum and hence increased the rate of its absorption into the blood and brain." @default.
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- W2020111689 date "1971-12-01" @default.
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- W2020111689 title "The effect of ethanol on phenobarbitone and pentobarbitone absorption into rat blood and brain" @default.
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- W2020111689 doi "https://doi.org/10.1111/j.2042-7158.1971.tb09898.x" @default.
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