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• W2020112095 abstract "Synaptic plasticity in the form of long-term potentiation (LTP) plays a critical role in the formation of a Pavlovian fear association. However, the role that synaptic plasticity plays in the suppression of a learned fear response remains to be clarified. Here, we assessed the role that long-term depression (LTD) plays in the acquisition, expression, and extinction of a conditioned fear response. We report that blockade of LTD with a GluR2-derived peptide (Tat-GluR23Y; 1.5 μmol/kg, i.v.) that blocks regulated α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor endocytosis during an initial extinction training session disrupted both the expression and recall of extinction learning. A similar impairment of extinction during training, but not recall, was observed when NMDA receptor-dependent LTD was inhibited through the selective blockade of NMDA NR2B receptors with Ro 25-6981. In contrast, blockade of LTD with Tat-GluR23Y during fear conditioning or during a fear recall test did not effect the expression or recall of either contextual or cue-induced conditioned fear. Similarly, administration of Tat-GluR23Y prior to an extinction recall test did not affect spontaneous recovery or rate of re-extinction in previously extinguished rats. These data demonstrate that AMPA receptor endocytosis does not mediate acquisition or expression of conditioned fear, but may play a role in the extinction of fear memories. Furthermore, these findings suggest that LTD may be a molecular mechanism that facilitates the selective modification of a learned association while leaving intact the ability to form a new memory." @default.
• W2020112095 created "2016-06-24" @default.
• W2020112095 creator A5034827079 @default.
• W2020112095 creator A5043318987 @default.
• W2020112095 creator A5047476496 @default.
• W2020112095 creator A5081137194 @default.
• W2020112095 date "2007-11-28" @default.
• W2020112095 modified "2023-10-14" @default.
• W2020112095 title "Disruption of AMPA Receptor Endocytosis Impairs the Extinction, but not Acquisition of Learned Fear" @default.
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• W2020112095 cites W1733248925 @default.
• W2020112095 cites W1791997487 @default.
• W2020112095 cites W1965303728 @default.
• W2020112095 cites W1971110401 @default.
• W2020112095 cites W1972434093 @default.
• W2020112095 cites W1972799025 @default.
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• W2020112095 doi "https://doi.org/10.1038/sj.npp.1301642" @default.
• W2020112095 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18046303" @default.
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