FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020112497> ?p ?o ?g. }

• W2020112497 endingPage "e54" @default.
• W2020112497 startingPage "e54" @default.
• W2020112497 abstract "Background Bidens pilosa Linn. var. radiata is a tropical weed widely present in tropical and subtropical regions, including Miyako Island, Okinawa, Japan. The whole plant or its leaves and stem are used in various folk medicines and as a popular ingredient in herbal tea for its anti-inflammatory, anti-septic, liver-protective, blood-pressure lowering, and hypoglycaemic effects. There are no reports of the effects of B. pilosa on human colorectal cancer cells. Methods We investigated the effects of B pilosa on the human carcinoma cell lines HCT116 and Caco-2. The former has wild-type p53, the latter has mutant p53. B pilosa was provided as an extract powder from Musashi Immune laboratory Co. (Miyako Island, Okinawa, Japan). Findings B pilosa (0.25, 0.5, and 1 mg/ml in medium) demonstrated dose-dependent growth inhibition on both cell lines, assessed by WST-8 assay (Nacalai Tesque, Kyoto, Japan). B pilosa induced apoptosis in both HCT116 and Caco-2 cell lines, assessed by DNA ladder. In addition, a cleaved caspase-8 was expressed in both cell lines, as assessed by western blot. In both cell lines, in spite of the p53-genetic status, B pilosa also increased the expression death receptor 5 (DR5), a TRAIL receptor that activates caspase-8, leading directly to the activation of caspase-3. Interpretation Our results suggest that B pilosa has the potential to prevent or treat for colon cancers through induction of apoptosis by a p53-independent pathway. Bidens pilosa Linn. var. radiata is a tropical weed widely present in tropical and subtropical regions, including Miyako Island, Okinawa, Japan. The whole plant or its leaves and stem are used in various folk medicines and as a popular ingredient in herbal tea for its anti-inflammatory, anti-septic, liver-protective, blood-pressure lowering, and hypoglycaemic effects. There are no reports of the effects of B. pilosa on human colorectal cancer cells. We investigated the effects of B pilosa on the human carcinoma cell lines HCT116 and Caco-2. The former has wild-type p53, the latter has mutant p53. B pilosa was provided as an extract powder from Musashi Immune laboratory Co. (Miyako Island, Okinawa, Japan). B pilosa (0.25, 0.5, and 1 mg/ml in medium) demonstrated dose-dependent growth inhibition on both cell lines, assessed by WST-8 assay (Nacalai Tesque, Kyoto, Japan). B pilosa induced apoptosis in both HCT116 and Caco-2 cell lines, assessed by DNA ladder. In addition, a cleaved caspase-8 was expressed in both cell lines, as assessed by western blot. In both cell lines, in spite of the p53-genetic status, B pilosa also increased the expression death receptor 5 (DR5), a TRAIL receptor that activates caspase-8, leading directly to the activation of caspase-3. Our results suggest that B pilosa has the potential to prevent or treat for colon cancers through induction of apoptosis by a p53-independent pathway." @default.
• W2020112497 created "2016-06-24" @default.
• W2020112497 creator A5016864036 @default.
• W2020112497 creator A5033819579 @default.
• W2020112497 creator A5064067724 @default.
• W2020112497 creator A5088507813 @default.
• W2020112497 date "2014-05-01" @default.
• W2020112497 modified "2023-09-27" @default.
• W2020112497 title "P0159 Bidens pilosa extract induces apoptosis through up-regulation of death receptor 5 in human colon carcinoma cell lines" @default.
• W2020112497 doi "https://doi.org/10.1016/j.ejca.2014.03.203" @default.
• W2020112497 hasPublicationYear "2014" @default.
• W2020112497 type Work @default.
• W2020112497 sameAs 2020112497 @default.
• W2020112497 citedByCount "2" @default.
• W2020112497 countsByYear W20201124972020 @default.
• W2020112497 countsByYear W20201124972022 @default.
• W2020112497 crossrefType "journal-article" @default.
• W2020112497 hasAuthorship W2020112497A5016864036 @default.
• W2020112497 hasAuthorship W2020112497A5033819579 @default.
• W2020112497 hasAuthorship W2020112497A5064067724 @default.
• W2020112497 hasAuthorship W2020112497A5088507813 @default.
• W2020112497 hasConcept C153911025 @default.
• W2020112497 hasConcept C190283241 @default.
• W2020112497 hasConcept C2778717339 @default.
• W2020112497 hasConcept C55493867 @default.
• W2020112497 hasConcept C59822182 @default.
• W2020112497 hasConcept C86803240 @default.
• W2020112497 hasConceptScore W2020112497C153911025 @default.
• W2020112497 hasConceptScore W2020112497C190283241 @default.
• W2020112497 hasConceptScore W2020112497C2778717339 @default.
• W2020112497 hasConceptScore W2020112497C55493867 @default.
• W2020112497 hasConceptScore W2020112497C59822182 @default.
• W2020112497 hasConceptScore W2020112497C86803240 @default.
• W2020112497 hasLocation W20201124971 @default.
• W2020112497 hasOpenAccess W2020112497 @default.
• W2020112497 hasPrimaryLocation W20201124971 @default.
• W2020112497 hasRelatedWork W2012644906 @default.
• W2020112497 hasRelatedWork W2027136333 @default.
• W2020112497 hasRelatedWork W2027989916 @default.
• W2020112497 hasRelatedWork W2047134548 @default.
• W2020112497 hasRelatedWork W2119976708 @default.
• W2020112497 hasRelatedWork W2468335957 @default.
• W2020112497 hasRelatedWork W2476588683 @default.
• W2020112497 hasRelatedWork W2981713487 @default.
• W2020112497 hasRelatedWork W3215139134 @default.
• W2020112497 hasRelatedWork W4240757957 @default.
• W2020112497 hasVolume "50" @default.
• W2020112497 isParatext "false" @default.
• W2020112497 isRetracted "false" @default.
• W2020112497 magId "2020112497" @default.
• W2020112497 workType "article" @default.