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- W2020116384 endingPage "16" @default.
- W2020116384 startingPage "9" @default.
- W2020116384 abstract "The pathogenesis of pulmonary arterial hypertension (PAH) is complex, involving multiple modulating genes and environmental factors. Multifactorial impairment of the physiologic balance can lead to vasoconstriction, vascular smooth muscle cell and endothelial cell proliferation/fibrosis, inflammation, remodeling and in-situ thrombosis. These are the likely mechanisms that lead to narrowing of the vessel followed by progressive increase in pulmonary vascular resistance and the clinical manifestations of pulmonary hypertension. Subsequently, major goal of the therapy is to avoid acute pulmonary vasoconstriction, halt the progression of vascular remodeling, and reverse the early vascular remodeling if possible. Recently published data addressing certain molecular mechanisms for pathogenesis of PAH have led to the successful therapeutic interventions. This review will focus on the common and critical molecular pathways including genetic basis of the development of PAH that on the whole may be new targets for therapeutic interventions." @default.
- W2020116384 created "2016-06-24" @default.
- W2020116384 creator A5072066193 @default.
- W2020116384 date "2009-05-01" @default.
- W2020116384 modified "2023-10-18" @default.
- W2020116384 title "Molecular mechanisms of pulmonary hypertension" @default.
- W2020116384 cites W102063167 @default.
- W2020116384 cites W1606441445 @default.
- W2020116384 cites W177395109 @default.
- W2020116384 cites W1910919161 @default.
- W2020116384 cites W1912376315 @default.
- W2020116384 cites W1963869815 @default.
- W2020116384 cites W1965550428 @default.
- W2020116384 cites W1966747350 @default.
- W2020116384 cites W1969802668 @default.
- W2020116384 cites W1972861299 @default.
- W2020116384 cites W1973720695 @default.
- W2020116384 cites W1974855677 @default.
- W2020116384 cites W1975079007 @default.
- W2020116384 cites W1975608072 @default.
- W2020116384 cites W1977777133 @default.
- W2020116384 cites W1980619986 @default.
- W2020116384 cites W1981443796 @default.
- W2020116384 cites W1983741275 @default.
- W2020116384 cites W1983815397 @default.
- W2020116384 cites W1986011611 @default.
- W2020116384 cites W1989862758 @default.
- W2020116384 cites W1991920897 @default.
- W2020116384 cites W1993387193 @default.
- W2020116384 cites W1993536085 @default.
- W2020116384 cites W1996468290 @default.
- W2020116384 cites W1996588278 @default.
- W2020116384 cites W1997356019 @default.
- W2020116384 cites W1997486462 @default.
- W2020116384 cites W1997632305 @default.
- W2020116384 cites W2000066568 @default.
- W2020116384 cites W2000228053 @default.
- W2020116384 cites W2005877134 @default.
- W2020116384 cites W2006178366 @default.
- W2020116384 cites W2007458222 @default.
- W2020116384 cites W2008286376 @default.
- W2020116384 cites W2009411008 @default.
- W2020116384 cites W2010282977 @default.
- W2020116384 cites W2011271404 @default.
- W2020116384 cites W2012065393 @default.
- W2020116384 cites W2012400171 @default.
- W2020116384 cites W2012851453 @default.
- W2020116384 cites W2015390870 @default.
- W2020116384 cites W2023703380 @default.
- W2020116384 cites W2024846221 @default.
- W2020116384 cites W2025593289 @default.
- W2020116384 cites W2029399343 @default.
- W2020116384 cites W2030470655 @default.
- W2020116384 cites W2037896891 @default.
- W2020116384 cites W2038473729 @default.
- W2020116384 cites W2039172749 @default.
- W2020116384 cites W2043826113 @default.
- W2020116384 cites W2045765413 @default.
- W2020116384 cites W2046099060 @default.
- W2020116384 cites W2048443661 @default.
- W2020116384 cites W2050384089 @default.
- W2020116384 cites W2052022195 @default.
- W2020116384 cites W2054833206 @default.
- W2020116384 cites W2056019136 @default.
- W2020116384 cites W2063665010 @default.
- W2020116384 cites W2065587652 @default.
- W2020116384 cites W2067413933 @default.
- W2020116384 cites W2068669920 @default.
- W2020116384 cites W2072597464 @default.
- W2020116384 cites W2073697256 @default.
- W2020116384 cites W2074507891 @default.
- W2020116384 cites W2077353379 @default.
- W2020116384 cites W2077563196 @default.
- W2020116384 cites W2078404836 @default.
- W2020116384 cites W2079210292 @default.
- W2020116384 cites W2079562282 @default.
- W2020116384 cites W2081737415 @default.
- W2020116384 cites W2083998789 @default.
- W2020116384 cites W2087221897 @default.
- W2020116384 cites W2089751994 @default.
- W2020116384 cites W2090311982 @default.
- W2020116384 cites W2090583091 @default.
- W2020116384 cites W2091379942 @default.
- W2020116384 cites W2091965408 @default.
- W2020116384 cites W2092266379 @default.
- W2020116384 cites W2093943199 @default.
- W2020116384 cites W2096393477 @default.
- W2020116384 cites W2096807231 @default.
- W2020116384 cites W2097382561 @default.
- W2020116384 cites W2098964347 @default.
- W2020116384 cites W2099110524 @default.
- W2020116384 cites W2099891637 @default.
- W2020116384 cites W2099934410 @default.
- W2020116384 cites W2101154639 @default.
- W2020116384 cites W2101768152 @default.
- W2020116384 cites W2102344094 @default.
- W2020116384 cites W2104199488 @default.
- W2020116384 cites W2105297145 @default.