Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020118544> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2020118544 endingPage "1481" @default.
- W2020118544 startingPage "1477" @default.
- W2020118544 abstract "Nasal absorption of L-phenylalanine (L-Phe) and D-phenylalanine (D-Phe) have been investigated in rats using an in vivo absorption technique. L-Phe was effectively absorbed into systematic circulation with peak plasma level at 45 min after nasal administration. The absolute nasal bioavailability was calculated to be 96.3% when 5 mg/kg dose was given to fasted rats. The absolute bioavailability declined to 66.8% when 12.5 mg/kg of L-Phe was given intranasally while the time to reach peak concentration remained at 45 min. The results substantiated previous in situ data that, despite its high polarity, L-Phe was transported across the rat nasal mucosa into blood stream by the large neutral amino acid (LNAA) carrier. The carrier showed partial saturation at higher doses. On the other hand, when 5 mg/kg of D-Phe was given intranasally, slow and incomplete absorption was observed resulting in a peak time of 60 min and an absolute bioavailability of only 35.2%, suggesting specificity of the carrier for natural L-amino acids." @default.
- W2020118544 created "2016-06-24" @default.
- W2020118544 creator A5040297353 @default.
- W2020118544 creator A5042879096 @default.
- W2020118544 creator A5085367342 @default.
- W2020118544 date "1991-01-01" @default.
- W2020118544 modified "2023-10-16" @default.
- W2020118544 title "Systematic absorption of L- and D-phenylalanine across the rat nasal mucosa" @default.
- W2020118544 cites W130964878 @default.
- W2020118544 cites W1576761510 @default.
- W2020118544 cites W1977666151 @default.
- W2020118544 cites W2016587975 @default.
- W2020118544 cites W2071686844 @default.
- W2020118544 cites W2165473561 @default.
- W2020118544 doi "https://doi.org/10.1016/0024-3205(91)90185-e" @default.
- W2020118544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2011051" @default.
- W2020118544 hasPublicationYear "1991" @default.
- W2020118544 type Work @default.
- W2020118544 sameAs 2020118544 @default.
- W2020118544 citedByCount "6" @default.
- W2020118544 countsByYear W20201185442021 @default.
- W2020118544 crossrefType "journal-article" @default.
- W2020118544 hasAuthorship W2020118544A5040297353 @default.
- W2020118544 hasAuthorship W2020118544A5042879096 @default.
- W2020118544 hasAuthorship W2020118544A5085367342 @default.
- W2020118544 hasConcept C125287762 @default.
- W2020118544 hasConcept C134018914 @default.
- W2020118544 hasConcept C150903083 @default.
- W2020118544 hasConcept C159985019 @default.
- W2020118544 hasConcept C181389837 @default.
- W2020118544 hasConcept C185592680 @default.
- W2020118544 hasConcept C192562407 @default.
- W2020118544 hasConcept C203014093 @default.
- W2020118544 hasConcept C207001950 @default.
- W2020118544 hasConcept C2777431362 @default.
- W2020118544 hasConcept C515207424 @default.
- W2020118544 hasConcept C55493867 @default.
- W2020118544 hasConcept C59377437 @default.
- W2020118544 hasConcept C71924100 @default.
- W2020118544 hasConcept C85663871 @default.
- W2020118544 hasConcept C86803240 @default.
- W2020118544 hasConcept C98274493 @default.
- W2020118544 hasConceptScore W2020118544C125287762 @default.
- W2020118544 hasConceptScore W2020118544C134018914 @default.
- W2020118544 hasConceptScore W2020118544C150903083 @default.
- W2020118544 hasConceptScore W2020118544C159985019 @default.
- W2020118544 hasConceptScore W2020118544C181389837 @default.
- W2020118544 hasConceptScore W2020118544C185592680 @default.
- W2020118544 hasConceptScore W2020118544C192562407 @default.
- W2020118544 hasConceptScore W2020118544C203014093 @default.
- W2020118544 hasConceptScore W2020118544C207001950 @default.
- W2020118544 hasConceptScore W2020118544C2777431362 @default.
- W2020118544 hasConceptScore W2020118544C515207424 @default.
- W2020118544 hasConceptScore W2020118544C55493867 @default.
- W2020118544 hasConceptScore W2020118544C59377437 @default.
- W2020118544 hasConceptScore W2020118544C71924100 @default.
- W2020118544 hasConceptScore W2020118544C85663871 @default.
- W2020118544 hasConceptScore W2020118544C86803240 @default.
- W2020118544 hasConceptScore W2020118544C98274493 @default.
- W2020118544 hasIssue "15" @default.
- W2020118544 hasLocation W20201185441 @default.
- W2020118544 hasLocation W20201185442 @default.
- W2020118544 hasOpenAccess W2020118544 @default.
- W2020118544 hasPrimaryLocation W20201185441 @default.
- W2020118544 hasRelatedWork W1972995470 @default.
- W2020118544 hasRelatedWork W2020118544 @default.
- W2020118544 hasRelatedWork W2059582382 @default.
- W2020118544 hasRelatedWork W2061409503 @default.
- W2020118544 hasRelatedWork W2075333805 @default.
- W2020118544 hasRelatedWork W2089408457 @default.
- W2020118544 hasRelatedWork W2090283026 @default.
- W2020118544 hasRelatedWork W2371201456 @default.
- W2020118544 hasRelatedWork W2405625298 @default.
- W2020118544 hasRelatedWork W2417964455 @default.
- W2020118544 hasVolume "48" @default.
- W2020118544 isParatext "false" @default.
- W2020118544 isRetracted "false" @default.
- W2020118544 magId "2020118544" @default.
- W2020118544 workType "article" @default.