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• W2020119625 abstract "Abstract Transplantation of the embryonic hypothalamus onto the choroidal pia of an adult female rat host offers unique opportunities for studies of the humoral and neural factors which regulate hypothalamic differentiation and the acquisition of neuroendocrine function. Our previous work established that the transplanted hypothalamus acquires immunoreactivity for a number of peptides (e.g., LHRH, somatostatin, neurophysin), the ability to sequestor 3 H-estradiol, and an organized median eminence-like structure with catecholamine fluorescence. This report presents initial data on three additional aspects of the hypothalamic transplants which are important to assess their ability to function: (1) Estrogen receptors are characterized and measured biochemically in transplants and their elaboration following transplantation is shown to be independent of the presence of gonadal steroids through the use of gonadectomized hosts. Estrogen-mediated induction of progestin receptor sites, a feature of the normal mature hypothalamus, is shown to occur in hypothalamic transplants in both intact and gonadectomized hosts. (2) Neurophysin immunostaining also develops in a seemingly normal manner in intact and in gonadectomized and adrenalectomized (GDX-ADX) hosts given corticosterone. However, preliminary observations on transplants into GDX-ADX hosts without corticosterone replacement suggest that glucocorticoids, which are present in the maternal and fetal blood, may increase the number and/or immunoreactivity of neurophysin-containing perikarya. (3) Initial experiments on bone growth in hypophysectomized hosts indicate that pituitary-hypothalamic cotransplants function to some extent to promote bone growth above the low level seen after total hypophysectomy of the host. It is unknown at this time the degree to which the hypothalamic cotransplant functions to drive the pituitary transplant." @default.
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• W2020119625 date "1980-01-01" @default.
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• W2020119625 title "Hormonal effects on development of transplanted embryonic hypothalamus" @default.
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• W2020119625 doi "https://doi.org/10.1016/0196-9781(80)90109-6" @default.
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