Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020120981> ?p ?o ?g. }
- W2020120981 endingPage "826" @default.
- W2020120981 startingPage "826" @default.
- W2020120981 abstract "Drug-induced injury to the liver can mimic any form of acute or chronic liver disease. Acute injury to the liver frequently is due to the action of cytochrome P450, which breaks down drugs into electrophiles or free radicals; these reactive metabolites can covalently bind to protein and unsaturated fatty acids or induce lipid peroxidation, respectively. These events may impair vital functions of the cell, such as maintenance of calcium homeostasis, leading to death; or hypothetically they may elicit a hypersensitivity reaction directed mainly at the liver. Glutathione and tocopherol play critical roles in cellular defense. Cholestatic disease caused by drugs results from a selective disturbance in bile secretion. Agents such as estrogens, chlorpromazine, and monohydroxy bile acids alter the chemical and physical properties of membranes, leading to impaired activity of carriers and pumps for bile acids and electrolytes. Certain drugs produce chronic liver disease that is pathologically identical to chronic active hepatitis, biliary cirrhosis, or alcoholic liver disease." @default.
- W2020120981 created "2016-06-24" @default.
- W2020120981 creator A5043356624 @default.
- W2020120981 date "1986-06-01" @default.
- W2020120981 modified "2023-10-03" @default.
- W2020120981 title "Drug-Induced Hepatotoxicity" @default.
- W2020120981 cites W103243094 @default.
- W2020120981 cites W1429481766 @default.
- W2020120981 cites W1511013913 @default.
- W2020120981 cites W1518841999 @default.
- W2020120981 cites W1596027979 @default.
- W2020120981 cites W1603127702 @default.
- W2020120981 cites W1604863183 @default.
- W2020120981 cites W160957105 @default.
- W2020120981 cites W1624534833 @default.
- W2020120981 cites W1655637944 @default.
- W2020120981 cites W1768585139 @default.
- W2020120981 cites W1823181824 @default.
- W2020120981 cites W1838233329 @default.
- W2020120981 cites W1858182200 @default.
- W2020120981 cites W1893832985 @default.
- W2020120981 cites W1905780384 @default.
- W2020120981 cites W1914552086 @default.
- W2020120981 cites W1928191868 @default.
- W2020120981 cites W1936243553 @default.
- W2020120981 cites W1942691359 @default.
- W2020120981 cites W1962443378 @default.
- W2020120981 cites W1966280666 @default.
- W2020120981 cites W1967684747 @default.
- W2020120981 cites W1968005725 @default.
- W2020120981 cites W1972269499 @default.
- W2020120981 cites W1979837603 @default.
- W2020120981 cites W1980029961 @default.
- W2020120981 cites W1981846085 @default.
- W2020120981 cites W1983688443 @default.
- W2020120981 cites W1984098014 @default.
- W2020120981 cites W1984754777 @default.
- W2020120981 cites W1986432160 @default.
- W2020120981 cites W1991433371 @default.
- W2020120981 cites W1992463039 @default.
- W2020120981 cites W1995629494 @default.
- W2020120981 cites W2002897920 @default.
- W2020120981 cites W2006762995 @default.
- W2020120981 cites W2007136485 @default.
- W2020120981 cites W2007248297 @default.
- W2020120981 cites W2008249413 @default.
- W2020120981 cites W2009576522 @default.
- W2020120981 cites W2010086480 @default.
- W2020120981 cites W2020218381 @default.
- W2020120981 cites W2024018261 @default.
- W2020120981 cites W2026955880 @default.
- W2020120981 cites W2027858926 @default.
- W2020120981 cites W2028127226 @default.
- W2020120981 cites W2029335737 @default.
- W2020120981 cites W2032126144 @default.
- W2020120981 cites W2039323398 @default.
- W2020120981 cites W2042437431 @default.
- W2020120981 cites W2045933065 @default.
- W2020120981 cites W2047904749 @default.
- W2020120981 cites W2049093755 @default.
- W2020120981 cites W2058123879 @default.
- W2020120981 cites W2058755860 @default.
- W2020120981 cites W2059308749 @default.
- W2020120981 cites W2060590070 @default.
- W2020120981 cites W2062956408 @default.
- W2020120981 cites W2064870875 @default.
- W2020120981 cites W2064952945 @default.
- W2020120981 cites W2065732506 @default.
- W2020120981 cites W2065997722 @default.
- W2020120981 cites W2066657415 @default.
- W2020120981 cites W2068273197 @default.
- W2020120981 cites W2069569316 @default.
- W2020120981 cites W2070194097 @default.
- W2020120981 cites W2073575281 @default.
- W2020120981 cites W2074965404 @default.
- W2020120981 cites W2078573578 @default.
- W2020120981 cites W2079363199 @default.
- W2020120981 cites W2082252534 @default.
- W2020120981 cites W2083003235 @default.
- W2020120981 cites W2088098389 @default.
- W2020120981 cites W2092957609 @default.
- W2020120981 cites W2093781831 @default.
- W2020120981 cites W2099922198 @default.
- W2020120981 cites W2107754720 @default.
- W2020120981 cites W2107860883 @default.
- W2020120981 cites W2109252254 @default.
- W2020120981 cites W2120285579 @default.
- W2020120981 cites W2121713073 @default.
- W2020120981 cites W2127951677 @default.
- W2020120981 cites W2128263054 @default.
- W2020120981 cites W2131101159 @default.
- W2020120981 cites W2132826785 @default.
- W2020120981 cites W2138128197 @default.
- W2020120981 cites W2155949788 @default.
- W2020120981 cites W2163023322 @default.
- W2020120981 cites W2171603185 @default.
- W2020120981 cites W2177022515 @default.
- W2020120981 cites W2177910735 @default.