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- W2020121280 abstract "<h3>To the Editor.</h3> —In their well-done study of the duration of survival benefit of zidovudine in patients with AIDS, Dr Lundgren and colleagues<sup>1</sup>comment that visual inspection of product-limit plots for our study<sup>2</sup>suggest a survival benefit of about 1 year's duration. Our observational study reported survival estimates on 352 patients who received zidovudine and 362 patients who did not receive zidovudine who were first diagnosed with AIDS from April 1987 through June 1989 and had longitudinal follow-up through June 1990. A total of 470 patients (66%) died during follow-up. When survival from diagnosis of AIDS was analyzed by a time-dependent Cox regression in a manner similar to Lundgren et al, we derived the results listed in the Table. A second time-dependent Cox regression analysis was also done using the following model: relative hazard (t) = exp(B1+[B2×time]), where B1 provides an estimate of the relative hazard of use vs" @default.
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- W2020121280 date "1994-10-05" @default.
- W2020121280 modified "2023-09-27" @default.
- W2020121280 title "The Efficacy of Zidovudine Is Time Limited" @default.
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- W2020121280 doi "https://doi.org/10.1001/jama.1994.03520130035018" @default.
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