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- W2020121350 abstract "The fast sodium channel is sensitive to a variety of toxins. Veratridine, batrachotoxin, sea anemone and scorpion neurotoxins act on the gating system of the Na’ channel [l-6] and change its ionic selectivity [2,7], thereby provoking 86Rb’ or 42K+ efflux from preloaded excitable cells [8,9]. This stimulated %Rb’ (or 42K+) efflux is blocked by tetrodotoxin. We have used this property to devise an in vitro assay with synaptosomes. ScTX,, and ATX,, stimulate 86Rb+ release through the Na’ channel without changing the synaptosomal membrane potential. Moreover, toxin-induced release of 86Rb+ requires the presence of Na’ (or Li’) in the externalmedium, suggesting that the formation of a conducting form of the Na’ channel is dependent upon both the action of toxins and the saturation of external Na’ sites." @default.
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- W2020121350 date "1980-12-01" @default.
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- W2020121350 title "An in vitro system to study the action potential sodium channel" @default.
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- W2020121350 doi "https://doi.org/10.1016/0014-5793(80)80358-9" @default.
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