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• W2020123006 endingPage "486" @default.
• W2020123006 startingPage "470" @default.
• W2020123006 abstract "Muscle contraction and relaxation result from the interplay between two elaborate cellular structures and the small molecule, Ca2+, which cycles between them. The contractile elements are formed as short, repeating segments referred to as sarcomeres ( 1. Huxley H.E. The mechanism of muscular contraction. Science. 1969; 164: 1356-1365 Crossref PubMed Google Scholar , 2. Huxley A. Muscular contraction. Annu Rev Physiol. 1988; 50: 1-16 Crossref PubMed Google Scholar ). Within sarcomeres, longitudinally aligned, centrally located, thick filaments contain myosin, the adenosine triphosphate (ATP)-activated motor for the generation of contractile force (Figure 1). Thick filaments interdigitate between similarly aligned thin filaments that are anchored at either end of the sarcomere, but free in the center, forming bipolar arrays. The interaction between myosin molecules, oriented in a bipolar manner within thick filaments, and actin molecules in the two opposed thin filaments, results in shortening of the sarcomere as the thin filaments are drawn toward the center of the sarcomere. Relaxation results from release of the interaction between thin and thick filaments. In skeletal and cardiac muscle, the physical interactions between actin and myosin are possible only when Ca2+ is bound to a low molecular weight, high affinity Ca2+ binding protein, troponin C ( 3. Zot A.S. Potter J.D. Structural aspects of troponin-tropomyosin regulation of skeletal muscle contraction. Annu Rev Biophys Biophys Chem. 1987; 16: 535-559 Crossref PubMed Google Scholar ). Troponin C is located within a heterotrimeric, globular troponin complex, attached to filamentous tropomyosin, so that it forms a regulatory structure within the thin filament." @default.
• W2020123006 created "2016-06-24" @default.
• W2020123006 creator A5033530415 @default.
• W2020123006 creator A5068839871 @default.
• W2020123006 date "1998-05-01" @default.
• W2020123006 modified "2023-10-13" @default.
• W2020123006 title "Malignant Hyperthermia and Central Core Disease: Disorders of Ca2 Release Channels11In collaboration with The American Physiological Society, Thomas E. Andreoli, MD, Editor" @default.
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