FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020124107> ?p ?o ?g. }

• W2020124107 endingPage "52" @default.
• W2020124107 startingPage "44" @default.
• W2020124107 abstract "Gene transfer to the tracheobronchial tree has been an active area of investigation since the discovery of the genetic defect in the cystic fibrosis transmembrane conductance regulator over two decades ago. Cystic fibrosis (CF) is the most common lethal monogeneic disorder for which there is no cure short of lung transplantation. The ultimate goal of gene therapy in CF is to achieve efficient gene transfer at a level and distribution in target tracheobronchial epithelial cells and submucosal gland cells, which results in the genotypic and phenotypic correction of CF. This article reviews the current challenges and limitations of postnatal gene therapy to the tracheobronchial tree, and the potential advantages of fetal gene therapy for CF. We review recent work with novel viral vectors to achieve extremely efficient gene transfer in target cells in the respiratory epithelium and submucosal glands in models that are representative of the developing human fetal trachea. Finally, we will examine the prospects for, limitations of, and regulatory challenges facing the translation of fetal gene therapy from research to clinical application." @default.
• W2020124107 created "2016-06-24" @default.
• W2020124107 creator A5030988494 @default.
• W2020124107 creator A5082901450 @default.
• W2020124107 date "2004-02-01" @default.
• W2020124107 modified "2023-09-25" @default.
• W2020124107 title "Gene transfer to the tracheobronchial tree: implications for fetal gene therapy for cystic fibrosis" @default.
• W2020124107 cites W1485992471 @default.
• W2020124107 cites W1598188453 @default.
• W2020124107 cites W1804390662 @default.
• W2020124107 cites W1922255142 @default.
• W2020124107 cites W1943985333 @default.
• W2020124107 cites W1963799836 @default.
• W2020124107 cites W1965024813 @default.
• W2020124107 cites W1968469725 @default.
• W2020124107 cites W1970638821 @default.
• W2020124107 cites W1971384581 @default.
• W2020124107 cites W1973467197 @default.
• W2020124107 cites W1974821414 @default.
• W2020124107 cites W1986769432 @default.
• W2020124107 cites W1990198989 @default.
• W2020124107 cites W1990991203 @default.
• W2020124107 cites W1991157268 @default.
• W2020124107 cites W2005750320 @default.
• W2020124107 cites W2007854533 @default.
• W2020124107 cites W2013534167 @default.
• W2020124107 cites W2015617337 @default.
• W2020124107 cites W2017558860 @default.
• W2020124107 cites W2019612944 @default.
• W2020124107 cites W2019656743 @default.
• W2020124107 cites W2026699829 @default.
• W2020124107 cites W2028719355 @default.
• W2020124107 cites W2038036971 @default.
• W2020124107 cites W2038453307 @default.
• W2020124107 cites W2047608515 @default.
• W2020124107 cites W2059445343 @default.
• W2020124107 cites W2065422942 @default.
• W2020124107 cites W2067502888 @default.
• W2020124107 cites W2072106807 @default.
• W2020124107 cites W2074444371 @default.
• W2020124107 cites W2075350162 @default.
• W2020124107 cites W2078920860 @default.
• W2020124107 cites W2079017842 @default.
• W2020124107 cites W2079555292 @default.
• W2020124107 cites W2079791074 @default.
• W2020124107 cites W2080589169 @default.
• W2020124107 cites W2082691223 @default.
• W2020124107 cites W2083362762 @default.
• W2020124107 cites W2084149528 @default.
• W2020124107 cites W2089217804 @default.
• W2020124107 cites W2096309023 @default.
• W2020124107 cites W2100394645 @default.
• W2020124107 cites W2107091598 @default.
• W2020124107 cites W2112048001 @default.
• W2020124107 cites W2113259183 @default.
• W2020124107 cites W2125375279 @default.
• W2020124107 cites W2139784464 @default.
• W2020124107 cites W2151514148 @default.
• W2020124107 cites W2154330857 @default.
• W2020124107 cites W2154803067 @default.
• W2020124107 cites W2159567933 @default.
• W2020124107 cites W2159588905 @default.
• W2020124107 cites W2164342253 @default.
• W2020124107 cites W2165135583 @default.
• W2020124107 cites W2167231609 @default.
• W2020124107 cites W2167403314 @default.
• W2020124107 cites W2420778433 @default.
• W2020124107 cites W3104531246 @default.
• W2020124107 doi "https://doi.org/10.1053/j.sempedsurg.2003.09.007" @default.
• W2020124107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14765370" @default.
• W2020124107 hasPublicationYear "2004" @default.
• W2020124107 type Work @default.
• W2020124107 sameAs 2020124107 @default.
• W2020124107 citedByCount "8" @default.
• W2020124107 countsByYear W20201241072012 @default.
• W2020124107 crossrefType "journal-article" @default.
• W2020124107 hasAuthorship W2020124107A5030988494 @default.
• W2020124107 hasAuthorship W2020124107A5082901450 @default.
• W2020124107 hasConcept C104317684 @default.
• W2020124107 hasConcept C111599444 @default.
• W2020124107 hasConcept C126322002 @default.
• W2020124107 hasConcept C142724271 @default.
• W2020124107 hasConcept C172680121 @default.
• W2020124107 hasConcept C2776385078 @default.
• W2020124107 hasConcept C2776938444 @default.
• W2020124107 hasConcept C2778428886 @default.
• W2020124107 hasConcept C2779234561 @default.
• W2020124107 hasConcept C529295009 @default.
• W2020124107 hasConcept C54355233 @default.
• W2020124107 hasConcept C60644358 @default.
• W2020124107 hasConcept C71924100 @default.
• W2020124107 hasConcept C86803240 @default.
• W2020124107 hasConceptScore W2020124107C104317684 @default.
• W2020124107 hasConceptScore W2020124107C111599444 @default.
• W2020124107 hasConceptScore W2020124107C126322002 @default.
• W2020124107 hasConceptScore W2020124107C142724271 @default.
• W2020124107 hasConceptScore W2020124107C172680121 @default.
• W2020124107 hasConceptScore W2020124107C2776385078 @default.

• next