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- W2020125071 abstract "Introduction: Chronic daily headache (CDH) represents a temporal profile of headache (15+ days/month; 4+ hours/day; >6 months). We report the first comprehensive and largest levetiracetam (LEV) trial in CDH. Methods: A 27-week, multi-centre, randomised, placebo-controlled, cross-over, phase III B study assessed efficacy of a target of 3 g/day LEV of 6 placebo tablets/day in CDH. Primary efficacy was headache-free rate (HFR) while secondary parameters were loss of diagnostic criteria; severity; duration; disability; associated features; pain; and quality of life. Results: Ninety-six patients were recruited (baseline HFR 10.4 ± 14.6%; median 0%). At onset of history 73 (74.1%) had migraine +/− aura and 35 (36.5%) had tension-type headache (TTH). Over the six months preceding recruitment 54 (56.3%) had migraine and 42 (43.8%) had TTH. Headache history was 22.6 ± 15.0 years (median 20.0). Eighty-eight received placebo and 89 received LEV with >80 receiving stable dose in either arm. LEV achieved 3.9% increased HFR over placebo, showing a trend but not significance. There was 9.9% increase in loss of CDH diagnostic criteria re: headache days/month for LEV over placebo ( p = .0325), reduced disability ( p = .0487) and reduced pain severity for LEV ( p = .0162). The Short-Form Quality of Life assessment instrument (SF-36) showed impaired mental health on LEV ( p = .001). Discussion: These findings conflict with reports of LEV efficacy, mandating placebo control in headache trials. Primary efficacy equated to one extra headache-free day/month with reduced disability and pain intensity. Mental health was reduced on LEV. The 10% loss of diagnostic criteria, decreased intensity and disability suggest a subpopulation with CDH where LEV remains a therapeutic option." @default.
- W2020125071 created "2016-06-24" @default.
- W2020125071 creator A5013598339 @default.
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- W2020125071 date "2010-11-08" @default.
- W2020125071 modified "2023-09-24" @default.
- W2020125071 title "Levetiracetam in chronic daily headache: A double-blind, randomised placebo-controlled study" @default.
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- W2020125071 doi "https://doi.org/10.1177/0333102410384886" @default.
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