FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020126377> ?p ?o ?g. }

• W2020126377 endingPage "255" @default.
• W2020126377 startingPage "250" @default.
• W2020126377 abstract "Abstract Silymarin is a natural flavonoid found in the seeds of the milk thistle ( Silybum marianum ). Accumulating evidence indicates that silymarin exerts preventive/protective effects in animals and humans against many diseases. This study aimed to evaluate the antinociceptive effect of silymarin in the tail flick and writhing reaction assays. To understand the mechanism of the antinociceptive effect, the interaction of silymarin and morphine on acetic acid‐induced reaction was examined. Moreover, the effect of naloxone as a narcotic receptor antagonist on silymarin‐induced antinociception was studied. The antioxidant potency of silymarin was assessed by measuring the level of total thiol molecules in serum and the free radical scavenging activity. Silymarin lowered significantly ( P < 0.05) the latency time in the tail flick test in a dose‐dependent fashion. In the writhing reaction assay, silymarin dose‐ and time‐dependently decreased the number of acetic acid‐induced contractions. Silymarin also enhanced the morphine produced antinociceptive effect, while pretreatment with naloxone resulted in antagonism of the silymarin‐induced antinociceptive effect, significantly ( P < 0.05). Additionally, silymarin elevated the total thiol molecule level in the serum, which latter antioxidant property was confirmed by the concentration‐dependent radical scavenging activity. The data suggest that the silymarin antinociceptive effect may be attributed to its interaction with the opioid system and its antioxidant capacity. Copyright © 2010 John Wiley & Sons, Ltd." @default.
• W2020126377 created "2016-06-24" @default.
• W2020126377 creator A5002309035 @default.
• W2020126377 creator A5004111251 @default.
• W2020126377 creator A5046813391 @default.
• W2020126377 creator A5066538768 @default.
• W2020126377 date "2011-02-01" @default.
• W2020126377 modified "2023-10-17" @default.
• W2020126377 title "Silymarin potentiates the antinociceptive effect of morphine in mice" @default.
• W2020126377 cites W1963760749 @default.
• W2020126377 cites W1969686168 @default.
• W2020126377 cites W1980297252 @default.
• W2020126377 cites W1984042925 @default.
• W2020126377 cites W2003227142 @default.
• W2020126377 cites W2007720003 @default.
• W2020126377 cites W2010674772 @default.
• W2020126377 cites W2011521753 @default.
• W2020126377 cites W2013221973 @default.
• W2020126377 cites W2020168919 @default.
• W2020126377 cites W2022723969 @default.
• W2020126377 cites W2022897566 @default.
• W2020126377 cites W2023961270 @default.
• W2020126377 cites W2027618948 @default.
• W2020126377 cites W2028597206 @default.
• W2020126377 cites W2037175900 @default.
• W2020126377 cites W2047062023 @default.
• W2020126377 cites W2056653713 @default.
• W2020126377 cites W2057323600 @default.
• W2020126377 cites W2059726407 @default.
• W2020126377 cites W2060544849 @default.
• W2020126377 cites W2065565632 @default.
• W2020126377 cites W2066504688 @default.
• W2020126377 cites W2067048578 @default.
• W2020126377 cites W2078120815 @default.
• W2020126377 cites W2085527615 @default.
• W2020126377 cites W2092215613 @default.
• W2020126377 cites W2127023036 @default.
• W2020126377 cites W2130312501 @default.
• W2020126377 cites W2135524891 @default.
• W2020126377 cites W2140682024 @default.
• W2020126377 cites W2149608846 @default.
• W2020126377 doi "https://doi.org/10.1002/ptr.3251" @default.
• W2020126377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20641059" @default.
• W2020126377 hasPublicationYear "2011" @default.
• W2020126377 type Work @default.
• W2020126377 sameAs 2020126377 @default.
• W2020126377 citedByCount "11" @default.
• W2020126377 countsByYear W20201263772012 @default.
• W2020126377 countsByYear W20201263772013 @default.
• W2020126377 countsByYear W20201263772014 @default.
• W2020126377 countsByYear W20201263772015 @default.
• W2020126377 countsByYear W20201263772016 @default.
• W2020126377 countsByYear W20201263772020 @default.
• W2020126377 countsByYear W20201263772021 @default.
• W2020126377 countsByYear W20201263772022 @default.
• W2020126377 crossrefType "journal-article" @default.
• W2020126377 hasAuthorship W2020126377A5002309035 @default.
• W2020126377 hasAuthorship W2020126377A5004111251 @default.
• W2020126377 hasAuthorship W2020126377A5046813391 @default.
• W2020126377 hasAuthorship W2020126377A5066538768 @default.
• W2020126377 hasConcept C15490471 @default.
• W2020126377 hasConcept C170493617 @default.
• W2020126377 hasConcept C185592680 @default.
• W2020126377 hasConcept C2776885963 @default.
• W2020126377 hasConcept C2777383412 @default.
• W2020126377 hasConcept C2777389121 @default.
• W2020126377 hasConcept C2778004101 @default.
• W2020126377 hasConcept C2778750930 @default.
• W2020126377 hasConcept C2780210117 @default.
• W2020126377 hasConcept C2781063702 @default.
• W2020126377 hasConcept C2909423643 @default.
• W2020126377 hasConcept C55493867 @default.
• W2020126377 hasConcept C556039675 @default.
• W2020126377 hasConcept C71924100 @default.
• W2020126377 hasConcept C98274493 @default.
• W2020126377 hasConceptScore W2020126377C15490471 @default.
• W2020126377 hasConceptScore W2020126377C170493617 @default.
• W2020126377 hasConceptScore W2020126377C185592680 @default.
• W2020126377 hasConceptScore W2020126377C2776885963 @default.
• W2020126377 hasConceptScore W2020126377C2777383412 @default.
• W2020126377 hasConceptScore W2020126377C2777389121 @default.
• W2020126377 hasConceptScore W2020126377C2778004101 @default.
• W2020126377 hasConceptScore W2020126377C2778750930 @default.
• W2020126377 hasConceptScore W2020126377C2780210117 @default.
• W2020126377 hasConceptScore W2020126377C2781063702 @default.
• W2020126377 hasConceptScore W2020126377C2909423643 @default.
• W2020126377 hasConceptScore W2020126377C55493867 @default.
• W2020126377 hasConceptScore W2020126377C556039675 @default.
• W2020126377 hasConceptScore W2020126377C71924100 @default.
• W2020126377 hasConceptScore W2020126377C98274493 @default.
• W2020126377 hasIssue "2" @default.
• W2020126377 hasLocation W20201263771 @default.
• W2020126377 hasLocation W20201263772 @default.
• W2020126377 hasOpenAccess W2020126377 @default.
• W2020126377 hasPrimaryLocation W20201263771 @default.
• W2020126377 hasRelatedWork W2038529969 @default.
• W2020126377 hasRelatedWork W2892230529 @default.
• W2020126377 hasRelatedWork W3011302807 @default.

• next