FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2020126410> ?p ?o ?g. }

• W2020126410 endingPage "163" @default.
• W2020126410 startingPage "154" @default.
• W2020126410 abstract "Objective. To evaluate the antiarthritic properties of 2-methoxyestradiol, an endogenous metabolite of estradiol, on type II collagen-induced arthritis (CIA) in DBA/1 mice. Methods. The effects of treatment with 2-methoxyestradiol on the development of CIA were evaluated clinically and histologically. The in vitro effects of 2-methoxyestradiol on lymphocyte and endothelial cell proliferation and differentiation were analyzed by standard methods. Results. The development of CIA was significantly suppressed by 2-methoxyestradiol. Incubation with 2-methoxyestradiol suppressed the in vitro proliferation of endothelial cells, indicating that this compound down-regulates angiogenesis. Endothelial cell production of nitric oxide (NO) was also down-regulated by 2-methoxyestradiol. In contrast to estradiol, 2-methoxyestradiol exerted neither detectable feminizing effects on the sex organs nor inhibition of leukocyte development in hematopoietic organs. Conclusion. The development of CIA is suppressed by 2-methoxyestradiol, possibly via inhibition of angiogenesis. Diminished NO production could be of importance in vivo because it is a potent proinflammatory mediator. Since 2-methoxyestradiol exerts only mild side effects compared with estradiol, it is an interesting candidate for therapeutic use in inflammatory diseases." @default.
• W2020126410 created "2016-06-24" @default.
• W2020126410 creator A5067766594 @default.
• W2020126410 creator A5082065959 @default.
• W2020126410 date "1997-01-01" @default.
• W2020126410 modified "2023-09-23" @default.
• W2020126410 title "Suppression of type II collagen-induced arthritis by the endogenous estrogen metabolite 2-methoxyestradiol" @default.
• W2020126410 cites W1481844387 @default.
• W2020126410 cites W1911942190 @default.
• W2020126410 cites W1970773503 @default.
• W2020126410 cites W1977131276 @default.
• W2020126410 cites W1983964043 @default.
• W2020126410 cites W1990802251 @default.
• W2020126410 cites W1994953189 @default.
• W2020126410 cites W1995379365 @default.
• W2020126410 cites W2002983094 @default.
• W2020126410 cites W2010018399 @default.
• W2020126410 cites W2035459111 @default.
• W2020126410 cites W2039593520 @default.
• W2020126410 cites W2047076468 @default.
• W2020126410 cites W2055796403 @default.
• W2020126410 cites W2065563651 @default.
• W2020126410 cites W2096428903 @default.
• W2020126410 cites W2096613751 @default.
• W2020126410 cites W2114298357 @default.
• W2020126410 cites W2122248986 @default.
• W2020126410 cites W2132002566 @default.
• W2020126410 cites W2143260418 @default.
• W2020126410 cites W2153667962 @default.
• W2020126410 cites W2168014904 @default.
• W2020126410 cites W2325381575 @default.
• W2020126410 doi "https://doi.org/10.1002/art.1780400120" @default.
• W2020126410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9008611" @default.
• W2020126410 hasPublicationYear "1997" @default.
• W2020126410 type Work @default.
• W2020126410 sameAs 2020126410 @default.
• W2020126410 citedByCount "82" @default.
• W2020126410 countsByYear W20201264102012 @default.
• W2020126410 countsByYear W20201264102013 @default.
• W2020126410 countsByYear W20201264102014 @default.
• W2020126410 countsByYear W20201264102016 @default.
• W2020126410 countsByYear W20201264102017 @default.
• W2020126410 countsByYear W20201264102020 @default.
• W2020126410 countsByYear W20201264102022 @default.
• W2020126410 crossrefType "journal-article" @default.
• W2020126410 hasAuthorship W2020126410A5067766594 @default.
• W2020126410 hasAuthorship W2020126410A5082065959 @default.
• W2020126410 hasConcept C126322002 @default.
• W2020126410 hasConcept C134018914 @default.
• W2020126410 hasConcept C150903083 @default.
• W2020126410 hasConcept C164027704 @default.
• W2020126410 hasConcept C16613235 @default.
• W2020126410 hasConcept C185592680 @default.
• W2020126410 hasConcept C207001950 @default.
• W2020126410 hasConcept C2776260442 @default.
• W2020126410 hasConcept C2776914184 @default.
• W2020126410 hasConcept C2777164284 @default.
• W2020126410 hasConcept C2777477808 @default.
• W2020126410 hasConcept C2780394083 @default.
• W2020126410 hasConcept C502942594 @default.
• W2020126410 hasConcept C519581460 @default.
• W2020126410 hasConcept C71924100 @default.
• W2020126410 hasConcept C86803240 @default.
• W2020126410 hasConcept C98274493 @default.
• W2020126410 hasConceptScore W2020126410C126322002 @default.
• W2020126410 hasConceptScore W2020126410C134018914 @default.
• W2020126410 hasConceptScore W2020126410C150903083 @default.
• W2020126410 hasConceptScore W2020126410C164027704 @default.
• W2020126410 hasConceptScore W2020126410C16613235 @default.
• W2020126410 hasConceptScore W2020126410C185592680 @default.
• W2020126410 hasConceptScore W2020126410C207001950 @default.
• W2020126410 hasConceptScore W2020126410C2776260442 @default.
• W2020126410 hasConceptScore W2020126410C2776914184 @default.
• W2020126410 hasConceptScore W2020126410C2777164284 @default.
• W2020126410 hasConceptScore W2020126410C2777477808 @default.
• W2020126410 hasConceptScore W2020126410C2780394083 @default.
• W2020126410 hasConceptScore W2020126410C502942594 @default.
• W2020126410 hasConceptScore W2020126410C519581460 @default.
• W2020126410 hasConceptScore W2020126410C71924100 @default.
• W2020126410 hasConceptScore W2020126410C86803240 @default.
• W2020126410 hasConceptScore W2020126410C98274493 @default.
• W2020126410 hasIssue "1" @default.
• W2020126410 hasLocation W20201264101 @default.
• W2020126410 hasLocation W20201264102 @default.
• W2020126410 hasOpenAccess W2020126410 @default.
• W2020126410 hasPrimaryLocation W20201264101 @default.
• W2020126410 hasRelatedWork W1970739379 @default.
• W2020126410 hasRelatedWork W1976093699 @default.
• W2020126410 hasRelatedWork W1995954745 @default.
• W2020126410 hasRelatedWork W2001265113 @default.
• W2020126410 hasRelatedWork W2013481652 @default.
• W2020126410 hasRelatedWork W2027748287 @default.
• W2020126410 hasRelatedWork W2109882125 @default.
• W2020126410 hasRelatedWork W2117408795 @default.
• W2020126410 hasRelatedWork W2168803779 @default.
• W2020126410 hasRelatedWork W2316545013 @default.
• W2020126410 hasVolume "40" @default.
• W2020126410 isParatext "false" @default.

• next