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• W2020126761 abstract "Aims: High expression of phosphatase of regenerating liver (PRL‐3) has been implicated in cancer invasion and metastasis, indicating a close link between PRL‐3 and cancer development. The aim was to investigate the significance of PRL‐3 expression in the prognosis of colonic cancer. Methods and results: Expression of PRL‐3 protein in tissue slides obtained from surgical resection of primary colonic cancer was measured by immunohistochemistry using a specific anti‐PRL‐3 monoclonal antibody. Archived tissue specimens from 273 colonic cancers and 236 matched specimens of adjacent normal colonic mucosa with a median follow‐up of 57 months were examined. Multivariate analysis showed that PRL‐3 was an independent prognostic marker for disease‐free survival [DFS; hazard ratio (HR) 1.538, P = 0.035]. More importantly, the expression of PRL‐3 showed significant negative correlation with DFS ( P = 0.018) in patients in the early stages (stage I and II). Patients with high levels of PRL‐3 expression in the adjacent normal mucosa also had a significant worse survival rate (DFS 0.0% versus 74.4%, P = 0.001), and PRL‐3 expression remained an independent prognostic marker for DFS (HR 3.0, 95% confidence interval 1.7, 5.3, P < 0.001). Conclusions: PRL‐3 may predict poor survival and act as a promising biomarker for individualized therapy for patients with colonic cancer, especially for those diagnosed at an early stage." @default.
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• W2020126761 date "2009-02-01" @default.
• W2020126761 modified "2023-10-15" @default.
• W2020126761 title "Prognostic value of PRL-3 overexpression in early stages of colonic cancer" @default.
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• W2020126761 doi "https://doi.org/10.1111/j.1365-2559.2009.03226.x" @default.
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