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- W2020127265 endingPage "611" @default.
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- W2020127265 abstract "The constitutive and cytokine-induced levels of major histocompatibility (MHC) class I expression are tightly controlled at the transcriptional level. In this study, it is shown that the cis-acting regulatory element site alpha of the MHC class I promoter is essential for the IFN gamma-induced transactivation of MHC class I gene expression through the ISRE. Moreover, it was discovered that the class II transactivator (CIITA), which is itself under the control of the IFN gamma induction pathway, strongly transactivates MHC class I gene expression and exerts its activity through site alpha. Therefore, site alpha is a crucial regulatory element, mediating the classic route of IFN gamma induction via the ISRE as well as a novel route of MHC class I transactivation involving CIITA." @default.
- W2020127265 created "2016-06-24" @default.
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- W2020127265 date "1997-05-01" @default.
- W2020127265 modified "2023-09-29" @default.
- W2020127265 title "Site α Is Crucial for Two Routes of IFNγ-Induced MHC Class I Transactivation: The ISRE-Mediated Route and a Novel Pathway Involving CIITA" @default.
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- W2020127265 doi "https://doi.org/10.1016/s1074-7613(00)80348-9" @default.
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