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- W2020127377 abstract "The objective of this study was to establish an accurate in vitro model for cutaneous absorption in anurans. The harvested perfused anuran pelvic limb (HPAPL) model maintains the anatomic and physiologic integrity of the skin from the pelvic limb, including the intact capillary network. Radiolabeled malathion was applied to the skin of the dorsal thigh, and perfusate was collected over a 6 h period. Residues from the skin surface, stratum externum, and dosed area beneath the stratum externum were analyzed. Kinetic parameters were calculated from these data. Absorption was significantly less for the HPAPL than previously reported for Teflon flow-through diffusion cells. However, partitioning effects were comparable. The HPAPL is an appropriate in vitro model for examining cutaneous absorption kinetics in the bullfrog." @default.
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- W2020127377 date "2006-11-01" @default.
- W2020127377 modified "2023-09-24" @default.
- W2020127377 title "Percutaneous malathion absorption in the harvested perfused anuran pelvic limb" @default.
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- W2020127377 doi "https://doi.org/10.1016/j.etap.2006.04.009" @default.
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