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• W2020127401 abstract "Antimicrobial peptides (AMP) are important effectors of the innate immune system. Although there is increasing evidence that AMPs influence bacteria in a multitude of ways, bacterial wall rupture plays the pivotal role in the bactericidal action of AMPs. Structurally, AMPs share many similarities with endogenous heparin-binding peptides with respect to secondary structure, cationicity, and amphipathicity.In this study, we show that RQA21 (RQAREHSERKKRRRESECKAA), a cationic and hydrophilic heparin-binding peptide corresponding to the C-terminal region of extracellular superoxide dismutase (SOD), exerts antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis and Candida albicans. The peptide was also found to induce membrane leakage of negatively charged liposomes. However, its antibacterial effects were abrogated in physiological salt conditions as well as in plasma.The results provide further evidence that heparin-binding peptide regions are multifunctional, but also illustrate that cationicity alone is not sufficient for AMP function at physiological conditions. However, our observation, apart from providing a link between heparin-binding peptides and AMPs, raises the hypothesis that proteolytically generated C-terminal SOD-derived peptides could interact with, and possibly counteract bacteria. Further studies are therefore merited to study a possible role of SOD in host defence." @default.
• W2020127401 created "2016-06-24" @default.
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• W2020127401 date "2009-01-01" @default.
• W2020127401 modified "2023-10-18" @default.
• W2020127401 title "Antimicrobial activity of a C-terminal peptide from human extracellular superoxide dismutase" @default.
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• W2020127401 doi "https://doi.org/10.1186/1756-0500-2-136" @default.
• W2020127401 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2717103" @default.
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