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- W2020127912 abstract "Treatment of cultured rat astrocytes with hypotonic media or with 1 mM glutamate for 90 min caused cell swelling and a significant increase in glycogen content. Conversely, treatment with hypertonic media caused cell shrinkage with a corresponding decrease in astrocyte glycogen, which was proportional to the increasing osmolality of the hypertonic media. The glutamate receptor antagonist, MK-801, lowered both the glutamate-induced swelling and glycogen increase. These findings demonstrate a correlation between changes in cell volume and astrocyte glycogen content. This may explain the increased astrocytic glycogen observed in many neuropathological conditions where astrocyte swelling occurs. Because glycogen represents the largest energy reserve in the central nervous system, a swelling-induced disturbance in glycogen metabolism may lead to abnormal glial-neuronal interactions resulting in impaired brain bioenergetics." @default.
- W2020127912 created "2016-06-24" @default.
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- W2020127912 date "2000-03-09" @default.
- W2020127912 modified "2023-10-05" @default.
- W2020127912 title "Association between cell swelling and glycogen content in cultured astrocytes" @default.
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- W2020127912 doi "https://doi.org/10.1016/s0736-5748(99)00084-2" @default.
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