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- W2020128527 abstract "Abstract Strain 13 guinea pigs infected with Pichinde virus have been commonly used as an animal model for studying pathophysiological mechanisms and treatment of human Lassa fever. During Pichinde virus infection of these animals, severe cardiac dysfunction and pulmonary edema develop, despite dehydration. The main purpose of this study was to develop techniques for measuring hemodynamic changes of four cardiac chambers and selected cardiovascular functions of control and Pichinde virus-infected strain 13 guinea pigs. Experiments were conducted on postinoculation days 7 and 11 in anesthetized, open-chest and mechanically ventilated guinea pigs. In virus-infected guinea pigs, arterial blood pressure, cardiac output, heart rate and left ventricular contractility decreased, while the total peripheral resistance and left atrial mean pressure increased significantly ( P" @default.
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- W2020128527 date "1998-09-01" @default.
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- W2020128527 title "Significance of hemodynamic changes in four cardiac chambers of guinea pigs infected with Pichinde virus" @default.
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