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• W2020129430 abstract "Palytoxin is one of the most toxic marine toxins known. Distributed worldwide, it poses a potential human health risk linked to the consumption of contaminated seafood. Despite its high parenteral toxicity, the lethal oral dose of palytoxin is several times higher than the intraperitoneal lethal dose. In the present study, we investigated the passage of palytoxin through the human intestinal barrier by employing a well‐characterized and accepted in vitro model of intestinal permeability that uses differentiated C aco‐2 cell monolayers. Trans‐epithelial electric resistance measurements showed that palytoxin disrupts the integrity of C aco‐2 monolayers at concentrations > 0.135 n m . However, confocal microscopy imaging showed that the tight‐junction protein occludin was not affected by palytoxin in the nanomolar range. This finding was supported by transmission electron microscopy imaging, where tight‐junctions appeared to be unaffected by palytoxin treatment. In addition, the nuclear envelope does not appear to be altered by high concentrations of palytoxin. However, palytoxin‐treated cells showed electron‐dense and damaged mitochondria. Toxin exposure also induced the disappearance of the differentiated C aco‐2 microvilli and organelles, as well as chromatin de‐condensation. Permeability assays showed that palytoxin could not significantly pass the C aco‐2 monolayer, despite the lack of epithelium integrity, suggesting that palytoxins would be poorly transported to blood, which may explain its lower oral toxicity. These data can help to achieve a better understanding of palytoxin poisoning. However, more studies regarding its repeated administration and chronic effects are needed." @default.
• W2020129430 created "2016-06-24" @default.
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• W2020129430 date "2013-07-05" @default.
• W2020129430 modified "2023-10-17" @default.
• W2020129430 title "The kinetic, mechanistic and cytomorphological effects of palytoxin in human intestinal cells (Caco-2) explain its lower-than-parenteral oral toxicity" @default.
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• W2020129430 cites W1556366271 @default.
• W2020129430 cites W1598124286 @default.
• W2020129430 cites W1967004579 @default.
• W2020129430 cites W1969870359 @default.
• W2020129430 cites W1972908905 @default.
• W2020129430 cites W1980776388 @default.
• W2020129430 cites W1985354493 @default.
• W2020129430 cites W1985767055 @default.
• W2020129430 cites W1987704865 @default.
• W2020129430 cites W1989886095 @default.
• W2020129430 cites W1994552648 @default.
• W2020129430 cites W1994696629 @default.
• W2020129430 cites W1995205054 @default.
• W2020129430 cites W2000073791 @default.
• W2020129430 cites W2000394436 @default.
• W2020129430 cites W2003776343 @default.
• W2020129430 cites W2006374650 @default.
• W2020129430 cites W2007728963 @default.
• W2020129430 cites W2009926052 @default.
• W2020129430 cites W2012364051 @default.
• W2020129430 cites W2015050411 @default.
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• W2020129430 cites W2017441577 @default.
• W2020129430 cites W2024472540 @default.
• W2020129430 cites W2024595488 @default.
• W2020129430 cites W2024870889 @default.
• W2020129430 cites W2026727928 @default.
• W2020129430 cites W2027589997 @default.
• W2020129430 cites W2028273867 @default.
• W2020129430 cites W2029943133 @default.
• W2020129430 cites W2030635244 @default.
• W2020129430 cites W2035246219 @default.
• W2020129430 cites W2036125618 @default.
• W2020129430 cites W2041454039 @default.
• W2020129430 cites W2042047871 @default.
• W2020129430 cites W2042442295 @default.
• W2020129430 cites W2042552566 @default.
• W2020129430 cites W2052532027 @default.
• W2020129430 cites W2053754060 @default.
• W2020129430 cites W2054415177 @default.
• W2020129430 cites W2065878733 @default.
• W2020129430 cites W2068585812 @default.
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• W2020129430 cites W2075503626 @default.
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• W2020129430 cites W2092480002 @default.
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• W2020129430 doi "https://doi.org/10.1111/febs.12390" @default.
• W2020129430 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23773601" @default.
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